Shaping the stress response: Interplay of palatable food choices, glucocorticoids, insulin and abdominal obesity
| Autor: | James P. Warne |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Hypothalamo-Hypophyseal System
endocrine system medicine.medical_specialty Calorie Corticotropin-Releasing Hormone medicine.medical_treatment Pituitary-Adrenal System Biochemistry Eating Food Preferences Endocrinology Stress Physiological Internal medicine Diabetes mellitus medicine Animals Humans Insulin Ingestion Chronic stress Obesity Glucocorticoids Molecular Biology Abdominal obesity Feedback Physiological business.industry digestive oral and skin physiology medicine.disease medicine.symptom business hormones hormone substitutes and hormone antagonists Glucocorticoid medicine.drug |
| Zdroj: | Molecular and Cellular Endocrinology. 300:137-146 |
| ISSN: | 0303-7207 |
| DOI: | 10.1016/j.mce.2008.09.036 |
| Popis: | Activity of the hypothalamo-pituitary-adrenal (HPA) axis is regulated by a negative feedback loop that dampens central drive of the axis via the actions of the secreted glucocorticoids. Conversely, under conditions of chronic stress, glucocorticoids delivered centrally increase hypothalamic paraventricular nucleus (PVN) corticotrophin-releasing factor (CRF) expression and the response to restraint. However, HPA axis activity and PVN CRF mRNA expression under chronic stress conditions are often reduced, implying other indirect peripheral or extra-hypothalamic glucocorticoid actions. Glucocorticoids chronically increase palatable food intake, which increases abdominal fat depots and circulating insulin levels, both of which negatively correlate with PVN CRF mRNA expression and may in turn dampen the response to stress. Such an effect is dependent on food choices, rather than total calories ingested. Considering stress is omnipresent in the workplace, palatable food ingestion may represent a means to combat the feeling of stress which is ultimately maladaptive when unresolved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect