Production of Ovarian Tumors by Hormone Administration
| Autor: | Sumio Araki |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Ovarian Neoplasms
medicine.medical_specialty medicine.drug_class Incidence (epidemiology) Rats Inbred Strains Neoplasms Experimental General Medicine Biology medicine.disease Androgen Hormones Rats Ovarian Cysts Endocrinology Estrogen Internal medicine Parenchyma medicine Animals Adenocarcinoma Female Tumor growth Sarcoma Hormone |
| Zdroj: | The Kurume Medical Journal. 28:35-43 |
| ISSN: | 1881-2090 0023-5679 |
| DOI: | 10.2739/kurumemedj.28.35 |
| Popis: | The influence of various extrinsic hormones was observed by using the clipping method to imbed and fix chemical carcinogens in the ovarian parenchyma. Among the hormones used, ACH and estrogen appeared to accelerate tumor growth. Although the incidence of solid tumors showed little difference among the test groups by the 20 th week, the incidence increased to 90% by the 40 th week in the ACH group. In hormone-given groups, incidence of tumors was low until the 20 th week, particularly in the androgen and progesteron groups. After that point the incidence of tumors incerased more in the hormone-given groups than in the control group. The estrogen group had the highest total incidence of cystic tumor, when compared with the control. The process of generating adenocarcinoma and sarcoma was fundamentally similar in the treated groups and the control. However, the time of appearance of tumors is the hormone-traced groups, except in the ACH group, differed from the control, particularly in the estrogen group. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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