High Incidence of Recurrent Wheeze in Children With Down Syndrome With and Without Previous Respiratory Syncytial Virus Lower Respiratory Tract Infection
| Autor: | Michel E. Weijerman, Reinoud J. B. J. Gemke, Beatrijs L.P. Bloemers, Louis Bont, Jan L. L. Kimpen, A. M. van Furth, Chantal J.M. Broers |
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| Přispěvatelé: | Pediatric surgery, CCA - Innovative therapy, EMGO - Lifestyle, overweight and diabetes, ICaR - Ischemia and repair |
| Rok vydání: | 2010 |
| Předmět: |
Male
Microbiology (medical) Pediatrics medicine.medical_specialty Paramyxoviridae viruses Respiratory Syncytial Virus Infections medicine.disease_cause Cohort Studies Recurrence Lower respiratory tract infection medicine Humans Prospective Studies Mononegavirales Respiratory Tract Infections Respiratory Sounds Retrospective Studies biology business.industry Incidence Respiratory disease Infant Pneumovirus biology.organism_classification medicine.disease Respiratory Syncytial Viruses respiratory tract diseases Pneumonia Infectious Diseases medicine.anatomical_structure Respiratory syncytial virus (RSV) Child Preschool Pediatrics Perinatology and Child Health Immunology Female Down Syndrome business Respiratory tract |
| Zdroj: | Bloemers, B, van Furth, A M, Weijerman, M E, Gemke, R J B J, Broers, C J M, Kimpen, J L L & Bont, L 2010, ' High Incidence of Recurrent Wheeze in Children With Down Syndrome With and Without Previous Respiratory Syncytial Virus Lower Respiratory Tract Infection ', Pediatric Infectious Disease Journal, vol. 29, no. 1, pp. 39-42 . https://doi.org/10.1097/INF.0b013e3181b34e52 Pediatric Infectious Disease Journal, 29(1), 39-42. Lippincott Williams and Wilkins |
| ISSN: | 0891-3668 |
| Popis: | Respiratory syncytial virus (RSV)-induced lower respiratory tract infection (LRTI) is associated with the subsequent development of recurrent wheeze. In a recent study, we found a high incidence (9.9%) of hospitalization for RSV-induced LRTI among children with Down syndrome (DS), indicating DS as a new risk factor for RSV-induced LRTI. In the current study we aimed to investigate the development of long-term airway morbidity in children with DS after hospitalization for RSV-induced LRTI.A combined retrospective cohort and prospective birth cohort of children with DS with a history of hospitalization for RSV-induced LRTI was studied (n = 53). Three control populations were included: children with DS without hospitalization for RSV-induced LRTI (n = 110), children without DS but with hospitalization for RSV-induced LRTI (n = 48), and healthy siblings of the previous 3 groups mentioned (n = 49). The primary outcome was physician-diagnosed wheeze up to 2 years of age.The incidence of physician-diagnosed recurrent wheeze in children with DS with a history of hospitalization for RSV-induced LRTI was 36%. Unexpectedly, up to 30% of children with DS without a history of RSV-induced LRTI had physician-diagnosed recurrent wheeze (no significant difference). In children without DS physician-diagnosed wheeze was found more frequently in children hospitalized for RSV-induced LRTI than healthy controls (31% vs. 8%, P = 0.004).In this combined retrospective/prospective cohort study RSV-induced LRTI did not significantly contribute to the risk of recurrent wheeze in children with DS. An unexpected finding was that recurrent wheeze was very common among children with DS. |
| Databáze: | OpenAIRE |
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