The effects of a highly purified hyaluronidase preparation on experimental myocardial infarction in the rat
| Autor: | J.-E. Nilsson, C. Sjögren, U. Säwe |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
medicine.medical_specialty
Coronary artery occlusion Necrosis medicine.medical_treatment Myocardial Infarction Infarction Hyaluronoglucosaminidase Hyaluronidase Internal medicine Occlusion Internal Medicine medicine Animals cardiovascular diseases Myocardial infarction Chemotherapy L-Lactate Dehydrogenase business.industry Rats Inbred Strains medicine.disease Rats Hyaluronidase preparation Anesthesia cardiovascular system Cardiology Drug Evaluation Cattle Female medicine.symptom business medicine.drug |
| Zdroj: | Acta medica Scandinavica. 216(2) |
| ISSN: | 0001-6101 |
| Popis: | Several substances have been claimed to be effective in reducing the area of necrosis in acute myocardial infarction. The effects of a highly purified hyaluronidase preparation (Hyalas) on experimental myocardial infarction in the rat have been evaluated in this study. In the first series, one group of rats was treated with hyaluronidase 1 500-2 000 IU/kg injected intravenously 2, 4, 18, 24, 28 and 42 hours after induction of infarction by coronary artery occlusion. Another group was treated with NaCl solution. The infarction size was evaluated by serum lactate dehydrogenase and weight of infarcted myocardium. In a second series, the substances were administered immediately after the occlusion. In this experiment, the infarction size was estimated by planimetry. The percentage of salvaged myocardium in the hyaluronidase-treated groups was within the range of 20%. It seems reasonable to suggest that the use of highly purified hyaluronidase may be of clinical value for reduction of the myocardial infarction size. |
| Databáze: | OpenAIRE |
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