The role of propofol on mouse oocyte meiotic maturation and early embryo development
| Autor: | Xiao-Bing Qi, Zai-Qing Huang, Xiao-Jun Zhi, Ling Ren, Cheng-Guang Liang, Sheng-Hui Luan, Chun-Guang Hao, Xia-Guang Duan |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Litter (animal) Embryonic Development Biology Fetal Development Andrology Mice 03 medical and health sciences Polar body Oogenesis 0302 clinical medicine Meiosis Pregnancy medicine Animals Propofol Cells Cultured 030219 obstetrics & reproductive medicine Pronucleus Embryogenesis Cell Biology Oocyte medicine.disease In Vitro Oocyte Maturation Techniques 030104 developmental biology medicine.anatomical_structure Oocytes Female Anesthetics Intravenous Developmental Biology medicine.drug |
| Zdroj: | Zygote. 26:261-269 |
| ISSN: | 1469-8730 0967-1994 |
| DOI: | 10.1017/s0967199418000163 |
| Popis: | SummaryPropofol is a intravenous anaesthetic most commonly used in ultrasound oocyte retrieval. We studied if the use of propofol had an effect on mouse oocyte maturation, pregnancy, childbirth and progeny and investigated the correlation between propofol side effects and reproductive performance in mice. There was no statistical difference in mating, pregnancy, childbirth, litter size, the number of stillbirths and survival between each group (P>0.05). Propofol also had no effect on polar body extrusion in oocyte maturation as well as on pronucleus formation and, subsequently, early embryo development (P>0.05). An increased concentration of propofol had no effect on this result, although propofol at more than 0.01 mg/ml reduced polar body extrusion. Different concentrations of propofol had no effect on oocyte culture in vitro, pronucleus formation and early embryo development. |
| Databáze: | OpenAIRE |
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