Differential patterns of postmigration HIV-1 infection acquisition among Portuguese immigrants of different geographical origins
| Autor: | Victor Figueiredo Pimentel, Marta Pingarilho, Giordano Sole, Daniela Alves, Mafalda Miranda, Isabel Diogo, Sandra Fernandes, Andrea Pineda-Pena, M. Rosário O. Martins, Ricardo Camacho, Perpétua Gomes, Ana B. Abecasis |
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| Přispěvatelé: | Instituto de Higiene e Medicina Tropical (IHMT), Global Health and Tropical Medicine (GHTM), TB, HIV and opportunistic diseases and pathogens (THOP), Population health, policies and services (PPS) |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | AIDS. 36:997-1005 |
| ISSN: | 1473-5571 0269-9370 |
| DOI: | 10.1097/qad.0000000000003203 |
| Popis: | OBJECTIVE: To investigate the dynamics of phylogenetic transmission clusters involving immigrants of Portuguese Speaking Countries living in Portugal. DESIGN/METHODS: We included genomic sequences, sociodemographic and clinical data from 772 HIV migrants followed in Portugal between 2001 and 2017. To reconstruct HIV-1 transmission clusters, we applied phylogenetic inference from 16 454 patients: 772 migrants, 2973 Portuguese and 12 709 global controls linked to demographic and clinical data. Transmission clusters were defined using: clusters with SH greater than 90% (phylogenetic support), genetic distance less than 3.5% and clusters that included greater than 66% of patients from one specific geographic origin compared with the total of sequences within the cluster. Logistic regression was performed to assess factors associated with clustering. RESULTS: Three hundred and six (39.6%) of migrants were included in transmission clusters. This proportion differed substantially by region of origin [Brazil 54% vs. Portuguese Speaking African Countries (PALOPs) 36%, P |
| Databáze: | OpenAIRE |
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