Orlistat improves endothelial function in obese adolescents: A randomised trial
| Autor: | Albert M. Li, Raymond C.H. So, Ping Chook, Chun T. Au, Karly O.W. Chan, Rita Y T Sung, Clare C.W. Yu, Alison M. McManus, Jack Tat-Chi Kam |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Adolescent medicine.medical_treatment Motor Activity Lactones chemistry.chemical_compound Weight loss Internal medicine medicine Humans Obesity Child Orlistat Anthropometry Triglyceride Cholesterol business.industry Insulin Endothelial Cells Blood Pressure Determination Fasting medicine.disease Blood pressure Endocrinology chemistry Pediatrics Perinatology and Child Health Hong Kong Female Anti-Obesity Agents medicine.symptom Energy Intake business Body mass index medicine.drug |
| Zdroj: | Journal of Paediatrics and Child Health. 49:969-975 |
| ISSN: | 1440-1754 1034-4810 |
| DOI: | 10.1111/jpc.12252 |
| Popis: | Aim To investigate the effect of orlistat on endothelial function in obese adolescents. Methods Single-blind 10-week controlled trial of 67 normolipidaemic obese adolescents randomised into three groups. Group 1 (diet alone), Group 2 (diet and orlistat), Group 3 (diet, orlistat and exercise). Endothelial function measured by flow-mediated dilatation (FMD) of the brachial artery, anthropometric parameters, blood pressure, fasting blood lipids, insulin and glucose levels were recorded at baseline and at 10 weeks. Results Sixty four subjects completed the study. Groups were comparable at baseline. FMD increased significantly with orlistat (Groups 2 and 3) but not in Group 1. Orlistat treatment resulted in significantly reduced bodyweight, body mass index (BMI), waist circumference, total and low-density lipoprotein (LDL) cholesterol levels. High-density lipoprotein cholesterol levels were unchanged. Triglyceride and insulin levels were significantly reduced in all three groups. The reduction in cholesterols did not correlate with reductions in weight and BMI. A slight reduction of body fat, both with and without orlistat treatment, correlated with reduction in BMI after adjustment for baseline values. Blood pressure was unaltered by orlistat. Calorie intake was reduced with orlistat, and the decrease noted in % fat and increase in % carbohydrate was significant only in those taking orlistat. The addition of exercise (Group 3 compared with Group 2) altered no parameter. Conclusions Orlistat improves endothelial function and reduces bodyweight, BMI, fasting total and LDL-cholesterol in obese adolescents when combined with dietary control. Improvement in endothelial function if maintained could reflect long-term cardiovascular benefit. |
| Databáze: | OpenAIRE |
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