Lactate dehydrogenase 5 isoenzyme overexpression defines resistance of prostate cancer to radiotherapy
| Autor: | S Mavropoulou, Stamatia Pouliliou, Efthimios Sivridis, Marianthi Panteliadou, P S Chondrou, Alexandra Giatromanolaki, M I Koukourakis |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Proliferation index medicine.medical_treatment Radiation Tolerance LDHA Prostate cancer Breast cancer DU145 Prostate Internal medicine Cell Line Tumor medicine Humans LDH5 Lung cancer radiotherapy Aged Cell Proliferation Aged 80 and over MIB1 L-Lactate Dehydrogenase business.industry hypofractionation Prostatic Neoplasms acceleration Middle Aged medicine.disease prostate cancer Cell Hypoxia Radiation therapy Isoenzymes medicine.anatomical_structure Lactate Dehydrogenase 5 Liver cancer business Translational Therapeutics Glycolysis |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Background: Radiotherapy provides high-cure rates in prostate cancer. Despite its overall slow clinical growth, high proliferation rates documented in a subset of tumours relate to poor radiotherapy outcome. This study examines the role of anaerobic metabolism in prostate cancer growth and resistance to radiotherapy. Methods: Biopsy samples from 83 patients with prostate cancer undergoing radical hypofractionated and accelerated radiotherapy were analysed for MIB1 proliferation index and for lactate dehydrogenase isoenzyme LDH5, a marker of tumour anaerobic metabolism. Ninety-five surgical samples were in parallel analysed. Correlation with histopathological variables, PSA and radiotherapy outcome was assessed. Dose–response experiments were performed in PC3 and DU145 cancer cell lines. Results: High MIB1 index (noted in 25% of cases) was directly related to Gleason score (P |
| Databáze: | OpenAIRE |
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