Sleep modulates effective connectivity: A study using intracranial stimulation and recording
| Autor: | Irina Popa, Andrei Barborica, Anca Adriana Arbune, Cristian Donos, Ioana Mindruta, Jean Ciurea, Sándor Beniczky, Ovidiu Bajenaru, Andrei Daneasa, Mihai Dragos Maliia |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Adolescent Deep Brain Stimulation Hippocampus Non-rapid eye movement sleep Functional Laterality 050105 experimental psychology Temporal lobe 03 medical and health sciences Epilepsy 0302 clinical medicine Single pulse electrical stimulation Physiology (medical) medicine Humans 0501 psychology and cognitive sciences Child Effective connectivity Evoked Potentials Neocortex business.industry 05 social sciences Middle Aged medicine.disease Brain Waves Sleep in non-human animals Sensory Systems medicine.anatomical_structure Neurology Frontal lobe stereo-EEG Female Wakefulness Neurology (clinical) business Sleep Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Arbune, A A, Popa, I, Mindruta, I, Beniczky, S, Donos, C, Daneasa, A, Mălîia, M D, Băjenaru, O A, Ciurea, J & Barborica, A 2020, ' Sleep modulates effective connectivity: A study using intracranial stimulation and recording ', Clinical Neurophysiology, vol. 131, no. 2, pp. 529-541 . https://doi.org/10.1016/j.clinph.2019.09.010 |
| Popis: | OBJECTIVE: Sleep is an active process with an important role in memory. Epilepsy patients often display a disturbed sleep architecture, with consequences on cognition. We aimed to investigate the effect of sleep on cortical networks' organization.METHODS: We analyzed cortico-cortical evoked responses elicited by single pulse electrical stimulation (SPES) using intracranial depth electrodes in 25 patients with drug-resistant focal epilepsy explored using stereo-EEG. We applied the SPES protocol during wakefulness and NREM - N2 sleep. We analyzed 31,710 significant responses elicited by 799 stimulations covering most brain structures, epileptogenic or non-epileptogenic. We analyzed effective connectivity between structures using a graph-theory approach.RESULTS: Sleep increases excitability in the brain, regardless of epileptogenicity. Local and distant connections are differently modulated by sleep, depending on the tissue epileptogenicity. In non-epileptogenic areas, frontal lobe connectivity is enhanced during sleep. There is increased connectivity between the hippocampus and temporal neocortex, while perisylvian structures are disconnected from the temporal lobe. In epileptogenic areas, we found a clear interhemispheric difference, with decreased connectivity in the right hemisphere during sleep.CONCLUSIONS: Sleep modulates brain excitability and reconfigures functional brain networks, depending on tissue epileptogenicity.SIGNIFICANCE: We found specific patterns of information flow during sleep in physiologic and pathologic structures, with possible implications for cognition. |
| Databáze: | OpenAIRE |
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