Bone marrow niches in myeloid neoplasms
Autor: | Masanobu Kitagawa, Iichiroh Onishi, Kouhei Yamamoto, Morito Kurata |
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Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Stromal cell Myeloid Hematopoietic stem cell niche Review Article Biology Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Bone Marrow hemic and lymphatic diseases MDS medicine Animals Humans Stem Cell Niche Myeloproliferative Disorders Cell growth Myelodysplastic syndromes hematopoietic stem cell niche General Medicine Hematopoietic Stem Cells medicine.disease microenvironment myeloid neoplasms Haematopoiesis 030104 developmental biology medicine.anatomical_structure Apoptosis Myelodysplastic Syndromes 030220 oncology & carcinogenesis Neoplastic Stem Cells Bone marrow |
Zdroj: | Pathology International |
ISSN: | 1440-1827 1320-5463 |
Popis: | Pathological phenotypes of myeloid neoplasms are closely related to genetic/chromosomal abnormalities of neoplastic cells whereas the bone marrow microenvironment, including stromal elements and hematopoietic stem cell niche cells, have a great influence on the differentiation/proliferation of both hematopoietic and neoplastic cells. The pathology of myeloid neoplasms might be generated through the interaction of hematopoietic (stem) cells and stromal cells. The present study aims to provide the morphological/functional aspects of the bone marrow environment in myeloid neoplasms. Among the myeloid neoplasms, myelodysplastic syndromes (MDS) exhibit significant and complex interactions between neoplastic cells and stromal cells. Hematopoietic cells in MDS are greatly influenced by macrophages/niche cells via several signaling pathways. As such, the pathological significance of cell proliferation, cell apoptosis, and anti-apoptosis signals in the bone marrow of myeloid neoplasms, especially MDS bone marrow, will be discussed. |
Databáze: | OpenAIRE |
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