The IGFs and their binding proteins in murine development
| Autor: | Liam J. Murphy, Douglas J. Barron |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
Genetically modified mouse medicine.medical_specialty medicine.medical_treatment Biology DNA-binding protein Embryonic and Fetal Development Mice Paracrine signalling Fetus Insulin-Like Growth Factor II Pregnancy Internal medicine Genetics medicine Animals Insulin-Like Growth Factor I Receptor Growth factor Embryogenesis Embryo Cell Biology Insulin-Like Growth Factor Binding Protein 1 Endocrinology Oviduct Female Carrier Proteins Developmental Biology |
| Zdroj: | Molecular Reproduction and Development. 35:376-381 |
| ISSN: | 1098-2795 1040-452X |
| DOI: | 10.1002/mrd.1080350410 |
| Popis: | Recent observations suggest that the diverse actions of the insulin-like growth factors (IGFs) are the result of interactions of the various components that make up the IGF system. The components of this system include IGF-I and -II and their variants, the type 1 and 2 IGF receptors and the insulin-like growth factor binding proteins (IGFBPs). Various components of the IGF system are expressed in the developing mouse embryo and the adjacent tissues of the reproductive tract in which the embryo develops. Thus there is the potential for paracrine interactions between the maternal and fetal tissues. Transcripts for the IGF receptors, IGF-I and IGF-II, have been demonstrated in the periimplantation mouse embryo. While there are now data from gene ablation experiments indicating that IGF-II is important in embryogenesis, the role of other components of the IGF system such as the IGFBPs remains unclear. The data accumulated so far are largely empirical, and there is as yet little compelling evidence that maternal IGFs derived from oviduct or uterine fluid and maternal tissues are necessary for normal fetal development. We have started to develop transgenic mice lines overexpressing IGFBPs to attempt to address the role of these binding proteins in fetal development. © 1993 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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