Predictive value of ADC mapping in discriminating probably benign and suspicious breast lesions
| Autor: | Osama Abdelaziz Elteeh, Mohamed H. Abowarda, Doaa Ibrahim Hasan |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
medicine.medical_specialty business.industry lcsh:R895-920 Diffusion-weighted imaging (DWI) Breast imaging reporting and data system (ACR-BIRADS) Predictive value Work-up Apparent diffusion coefficient value (ADC) Dynamic contrast Radiology Nuclear Medicine and imaging Medicine Effective diffusion coefficient Radiology Nuclear Medicine and imaging Radiology American College of Radiology business Nuclear medicine |
| Zdroj: | The Egyptian Journal of Radiology and Nuclear Medicine, Vol 46, Iss 2, Pp 545-551 (2015) |
| ISSN: | 0378-603X |
| DOI: | 10.1016/j.ejrnm.2015.02.004 |
| Popis: | Purpose The purpose of this study was to evaluate the usefulness of apparent diffusion coefficient (ADC value) in differentiating between probably benign breast lesions and, suspicious lesions (ACR-BIRADS categories 3 and 4 respectively). Patients and methods Breast lesions meeting study criteria were identified on dynamic contrast enhanced (DCE)-MRI examinations in 48 women over the course of the study period for 2 years. We found 27 (56.2%) of the cases probably benign as their BIRADS category 3 and the remaining 21 (43.7%) cases were category 4. Images were obtained with diffusion sensitizing gradients of 0 and 750 mm2/s. The apparent diffusion coefficient (ADC) was calculated and correlated with the histological data. Results The ADC values recorded a sensitivity of 97.9% and a specificity of 80%. The positive predictive value was 95.7% in differentiation between the benign and suspicious breast lesions. The difference in mean ADC for benign breast lesions (BIRADS-3, 1.45 ± 0.46 × 10−3 mm2/s), and suspicious lesions (BIRADS-4, 1.06 ± 0.56 × 10−3 mm2/s) was statistically significant. Conclusion Including the ADC diffusion coefficient in the diagnostic work up of patients with indeterminate breast lesions can help in the differentiation between benign and malignant breast lesions. |
| Databáze: | OpenAIRE |
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