Mediators of joint swelling and damage in rheumatoid arthritis and pristane induced arthritis
| Autor: | Christopher J. Elson, K. D. Bhoola, Stephen J. Thompson, C. I. Westacott |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
musculoskeletal diseases
medicine.medical_treatment T-Lymphocytes Immunology Inflammation Arthritis Rheumatoid Mice Heat shock protein medicine Immunology and Allergy Animals Humans Heat-Shock Proteins business.industry Terpenes Cartilage medicine.disease Immune complex Disease Models Animal Cytokine medicine.anatomical_structure Rheumatoid arthritis Mice Inbred CBA Liberation Tumor necrosis factor alpha Joints medicine.symptom business |
| Zdroj: | Autoimmunity. 13(4) |
| ISSN: | 0891-6934 |
| Popis: | Joint swelling and tenderness in rheumatoid arthritis (RA) probably result from IgG aggregates activating complement with the consequent attraction of polymorphonuclear leucocytes (PMNs) and the liberation of their granule enzymes such as kininogenases. By contrast IL-1 and TNF are the major stimulants of cartilage and bone loss although other agents contribute. The fundamental drive for the production of these mediators is unknown but a role for heat shock proteins is suggested from work on pristane induced arthritis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|