Design, synthesis, and biological activity evaluation of campthothecin-HAA-Norcantharidin conjugates as antitumor agents in vitro

Autor: Chan Li, Mei Huang, Xian H. Wang, Lang Xu, Chang K. Zhao
Rok vydání: 2018
Předmět:
Zdroj: Chemical biologydrug design. 93(6)
ISSN: 1747-0285
Popis: Three components of Camptothecin, hydroxyacetic acid, and functionalized norcantharidins were constructed together to form a novel series of camptothecin derivatives in a good yield. The synthesized campthothecin-HAA-norcantharidin conjugate pro-drugs could suppress cancer cell growth in vitro. These conjugated pro-drug molecules possess therapeutic potential as novel bi-functional conjugates platforms for cancer treatment.
Databáze: OpenAIRE
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