Design, synthesis, and biological activity evaluation of campthothecin-HAA-Norcantharidin conjugates as antitumor agents in vitro
Autor: | Chan Li, Mei Huang, Xian H. Wang, Lang Xu, Chang K. Zhao |
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Rok vydání: | 2018 |
Předmět: |
Conjugated system
01 natural sciences Biochemistry chemistry.chemical_compound Cell Line Tumor Drug Discovery medicine Humans Pharmacology Norcantharidin 010405 organic chemistry Chemistry Organic Chemistry Biological activity Prodrug Bridged Bicyclo Compounds Heterocyclic Combinatorial chemistry Antineoplastic Agents Phytogenic In vitro 0104 chemical sciences 010404 medicinal & biomolecular chemistry Drug Design Cancer cell Molecular Medicine Camptothecin Drug Screening Assays Antitumor medicine.drug Conjugate |
Zdroj: | Chemical biologydrug design. 93(6) |
ISSN: | 1747-0285 |
Popis: | Three components of Camptothecin, hydroxyacetic acid, and functionalized norcantharidins were constructed together to form a novel series of camptothecin derivatives in a good yield. The synthesized campthothecin-HAA-norcantharidin conjugate pro-drugs could suppress cancer cell growth in vitro. These conjugated pro-drug molecules possess therapeutic potential as novel bi-functional conjugates platforms for cancer treatment. |
Databáze: | OpenAIRE |
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