Screening of 12 Gliomata Against Chemotherapeutic Agents in Vitro
| Autor: | Dorothy M. Easty, John A. H. Wylie |
|---|---|
| Rok vydání: | 1963 |
| Předmět: |
Nerve degeneration
Vitamin Pediatrics medicine.medical_specialty business.industry General Engineering Signs and symptoms Articles General Medicine Parenteral therapy Bioinformatics chemistry.chemical_compound chemistry medicine General Earth and Planetary Sciences Vitamin B12 business General Environmental Science |
| Zdroj: | BMJ. 1:1589-1592 |
| ISSN: | 1468-5833 0959-8138 |
| DOI: | 10.1136/bmj.1.5345.1589 |
| Popis: | observations are perhaps worthy of mention. Firstly, whereas with crystalline vitamin B12 very little further improvement can be expected after six months* paren teral therapy (Ungley, 1949), in most of our cases a steady improvement was noticed over the first two years of treatment. Secondly, on parenteral therapy, according to Denny-Brown (1959), it is " unlikely that signs that have been present for months can be reversed." In the present series, however, although the symptoms in 8 of the 11 cases were of six months' duration or more, some improvement in the initial signs occurred in all except one case (No. 71). Finally, much has been heard during the past few years about the significance of vitamin-B12 levels in the serum on vitamin-B12-peptide therapy. It has been widely assumed that because low serum-vitamin-B12 levels were found to be the gloomy heralds of haemato logical and neurological disaster when patients were receiving intrinsic-factor preparations, a similar inter pretation of low levels was also justifiable on vitamin B12-peptide therapy. Our preparations, however, are not intrinsic-factor preparations, and the assumption, therefore, that low serum levels have the same significance on both forms of therapy is still unproved. We believe, in fact (Mooney and Heathcote, 1961b ; Heathcote and Mooney, 1961), that serum-vitamin-B12 levels have little practical value in vitamin-B]2-peptide therapy, and in this connexion it is noteworthy that one patient (Case 67) has achieved complete recovery not only from all signs and symptoms of anaemia but also from nerve degeneration, although his serum-vitamin-B12 level has never exceeded 55 /^g./ml. |
| Databáze: | OpenAIRE |
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