Oxygenated cembranoids of the decaryiol type from the Indonesian soft coral Lobophytum sp

Autor:	Orazio Taglialatela-Scafati, Adriana Romano, Giorgio Bavestrello, Ernesto Fattorusso, Carlo Irace, Carlo Cerrano, Carmen Maffettone
Přispěvatelé:	Fattorusso, Ernesto, Romano, Adriana, TAGLIALATELA SCAFATI, Orazio, Irace, Carlo, Maffettone, Carmen, G., Bavestrello, C., Cerrano
Rok vydání:	2009
Předmět:	food.ingredient Bicyclic molecule Chemistry Stereochemistry Coral Organic Chemistry Biochemistry Lobophytum Chemical synthesis Terpenoid Terpene chemistry.chemical_compound food Drug Discovery Chemical conversion Diterpene
Zdroj:	Tetrahedron. 65:2898-2904
ISSN:	0040-4020
DOI:	10.1016/j.tet.2009.02.008
Popis:	Three novel cembrane diterpenoids, decaryiols B–D (5–7), characterized by a bicyclic skeleton of the decaryiol-type, have been isolated from the Indonesian soft coral Lobophytum sp., along with three known cembranoids. The stereostructures of these metabolites have been established through extensive NMR spectroscopic analysis, application of the modified Mosher method, and chemical conversion. Cembranoids obtained from Lobophytum sp. (2–7) and six semisynthetic derivatives (9–14) prepared from decaryiol were tested for cell growth inhibitory activity against three different cell lines. O-Methyl decaryiol (10) exhibited a significant and selective activity against glioma cell lines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a84c2f295c9c5b400f7454c416619cc1 https://doi.org/10.1016/j.tet.2009.02.008 Zobrazit plný text záznamu Full Text from ScienceDirect