Non-β-cell tumor hypoglycemia associated with increased nonsuppressible insulin-like protein (NSILP)
| Autor: | Thomas T. Aoki, Herbert Plovnick, Elliott W. Chideckel, Philip L. Poffenbarger, Neil B. Ruderman |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Blood Glucose
medicine.medical_specialty medicine.medical_treatment Hypoglycemia Nonsuppressible Insulin-Like Activity Glucagon Internal medicine medicine Humans Insulin Lipolysis Amino Acids Pyruvates Fibrosarcoma Aged Alanine chemistry.chemical_classification business.industry Liver Neoplasms Sarcoma Fasting General Medicine medicine.disease Amino acid Endocrinology chemistry Lactates Ketone bodies Female business |
| Zdroj: | The American Journal of Medicine. 66:154-159 |
| ISSN: | 0002-9343 |
| DOI: | 10.1016/0002-9343(79)90508-4 |
| Popis: | An elderly woman with a massive intra-abdominal fibrosarcoma was noted to have intermittent hypoglycemia . When present, the hypoglycemia was associated with diminished levels of free fatty acids and ketone bodies and an increase in plasma NSILP . Lesser elevations of NSILP were observed on two of three occasions when the patient was normoglycemic. Insulin, somatomedin-C and NSILA-s levels were always low. Plasma glucagon increased appropriately in response to hypoglycemia; however, on three occasions, the plasma glucose response to intravenously administered glucagon was blunted. Low levels of amino acids were detected at all times; the concentration of alanine , the major gluconeogenic amino acid, was particularly low and diminished still further during several fasts during which the patient became hypoglycemic. Exogenous alanine caused a modest increase in plasma glucose. Thus, hypoglycemia was associated with hypoalaninemia, inhibition of lipolysis and impaired responsiveness to glucagon. To our knowledge, this is the first report of tumor-induced hypoglycemia associated with increased plasma NSILP. |
| Databáze: | OpenAIRE |
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