Effects of indoor particulate matter exposure on daily asthma control
| Autor: | Syed Hussain, Sherif Gonem, Roland Leigh, Joanne Finch, Sarah Parker, Antoine P. R. Jeanjean, Karen Edwards |
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| Rok vydání: | 2019 |
| Předmět: |
Pulmonary and Respiratory Medicine
Spirometry Male Immunology Arthropod Proteins 03 medical and health sciences 0302 clinical medicine Indoor air quality immune system diseases Environmental health Surveys and Questionnaires medicine Immunology and Allergy Animals Humans 030212 general & internal medicine Antigens Dermatophagoides Prospective Studies Asthma House dust mite medicine.diagnostic_test biology business.industry Pyroglyphidae Dust Environmental exposure Environmental Exposure Particulates Allergens Immunoglobulin E Middle Aged medicine.disease biology.organism_classification respiratory tract diseases Cysteine Endopeptidases 030228 respiratory system Asthma Control Questionnaire Air Pollution Indoor Exhaled nitric oxide Quality of Life Female Particulate Matter business |
| Zdroj: | Annals of allergy, asthmaimmunology : official publication of the American College of Allergy, Asthma,Immunology. 123(4) |
| ISSN: | 1534-4436 |
| Popis: | Background Household dust often contains aeroallergens, such as the house dust mite antigen Der p 1. It has been proposed that overnight exposure to particulate matter from bedding and other sources may be an important driver of atopic asthma. Whether variability in overnight particulate matter exposure is a significant determinant of asthma control is unknown. Objective To test the hypothesis that overnight particulate matter exposure is associated with day-to-day symptoms, lung function, and airway inflammation in patients with asthma who are sensitized to house dust mite. Methods We undertook a prospective, single-center panel study in 28 adults with asthma and house dust mite sensitization. Overnight exposure to particulate matter was measured using a commercially available indoor air quality monitor. Symptom scores, peak expiratory flow, and exhaled nitric oxide were measured and electronically recorded daily. Participants were followed up for 12 weeks and attended study visits every 4 weeks, at which they underwent spirometry and completed the Asthma Control Questionnaire and Asthma Quality of Life Questionnaire. Data were analyzed using cross-correlation and linear mixed-effects models. Results No significant associations were observed between overnight particulate matter exposure and clinical outcomes measured daily or at study visits. Conclusion Natural variability in overnight particulate matter exposure does not appear to be a major determinant of daily asthma control in patients with asthma and house dust mite sensitization. |
| Databáze: | OpenAIRE |
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