Plasma proteins predict conversion to dementia from prodromal disease
| Autor: | Patrizia Mecocci, Abdul Hye, Richard Dobson, Michelle K. Lupton, Iwona Kłoszewska, Hans Dieter Zucht, Danielle Pepin, Bruno Vellas, Nicholas J. Ashton, Eric Westman, Jill C. Richardson, Chantal Bazenet, Wei Zheng, Alan Tunnicliffe, Hilkka Soininen, Ian Pike, Alison L. Baird, Malcolm Ward, Simon Lovestone, Magda Tsolaki, Katie Lunnon, Rufina Leung, Andrew Simmons, Joanna Riddoch-Contreras, Serge Gauthier, Martina Sattlecker, Aoife Keohane |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Oncology
Male Pathology Epidemiology Statistics as Topic Disease Cohort Studies Plasma 0302 clinical medicine Cognitive decline Aged 80 and over Immunoassay 0303 health sciences Health Policy Blood Proteins Alzheimer's disease Magnetic Resonance Imaging Psychiatry and Mental health Predictive value of tests Disease Progression Biomarker (medicine) Female Cohort study medicine.medical_specialty Clinical Neurology Prodromal Symptoms 03 medical and health sciences Cellular and Molecular Neuroscience Apolipoproteins E Developmental Neuroscience Neuroimaging Predictive Value of Tests Internal medicine medicine Dementia Humans Cognitive Dysfunction 030304 developmental biology Aged business.industry Mild cognitive impairment Biomarker medicine.disease Clinical trial ROC Curve Prediction and magnetic resonance imaging Neurology (clinical) Geriatrics and Gerontology business Mental Status Schedule 030217 neurology & neurosurgery |
| Zdroj: | Hye, A, Riddoch-Contreras, J, Baird, A L, Ashton, N, Bazenet, C, Leung, R, Westman, E, Simmons, A, Dobson, R, Sattlecker, M, Lupton, M, Lunnon, K, Keohane, A, Ward, M, Pike, I, Zucht, H D, Pepin, D, Zheng, W, Tunnicliffe, A, Richardson, J, Gauthier, S, Soininen, H, Kłoszewska, I, Mecocci, P, Tsolaki, M, Vellas, B & Lovestone, S 2014, ' Plasma proteins predict conversion to dementia from prodromal disease ', Alzheimers & Dementia, vol. 10, no. 6, pp. 799–807.e2 . https://doi.org/10.1016/j.jalz.2014.05.1749 |
| DOI: | 10.1016/j.jalz.2014.05.1749 |
| Popis: | BackgroundThe study aimed to validate previously discovered plasma biomarkers associated with AD, using a design based on imaging measures as surrogate for disease severity and assess their prognostic value in predicting conversion to dementia.MethodsThree multicenter cohorts of cognitively healthy elderly, mild cognitive impairment (MCI), and AD participants with standardized clinical assessments and structural neuroimaging measures were used. Twenty-six candidate proteins were quantified in 1148 subjects using multiplex (xMAP) assays.ResultsSixteen proteins correlated with disease severity and cognitive decline. Strongest associations were in the MCI group with a panel of 10 proteins predicting progression to AD (accuracy 87%, sensitivity 85%, and specificity 88%).ConclusionsWe have identified 10 plasma proteins strongly associated with disease severity and disease progression. Such markers may be useful for patient selection for clinical trials and assessment of patients with predisease subjective memory complaints. |
| Databáze: | OpenAIRE |
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