Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes
| Autor: | Eric W. Triplett, Riitta Veijola, Mark A. Atkinson, Heikki Hyöty, Juha Mykkänen, Olli Simell, Kaisa M. Kemppainen, Ville Simell, Mikael Knip, Austin G. Davis-Richardson, Alexandria N. Ardissone, Jorma Ilonen, Jorma Toppari, Noora Nurminen, Raquel Dias, Michael T. Leonard, Tuula Simell, Bryan Kolaczkowski, Desmond A. Schatz, Jennifer C. Drew |
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| Přispěvatelé: | Tampere University, Department of Paediatrics, School of Medicine, Clinicum, Children's Hospital, Lastentautien yksikkö, Diabetes and Obesity Research Program, Research Programs Unit, HUS Children and Adolescents |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Bacteroides dorei
lcsh:QR1-502 microbiome Gut flora SUSCEPTIBILITY lcsh:Microbiology CELL AUTOIMMUNITY 0302 clinical medicine 3123 Gynaecology and paediatrics Original Research Article Autoimmunity4 1183 Plant biology microbiology virology Bacteroides dorei1 2. Zero hunger 0303 health sciences TREATMENT PARTIALLY PROTECTS biology Incidence (epidemiology) autoimmunity Microbiome5 3. Good health ESCHERICHIA-COLI type-1 diabetes ANTIBIOTIC-TREATMENT Bacteroides vulgatus Microbiology (medical) Type-1 Diabetes3 education 030209 endocrinology & metabolism HIGH-THROUGHPUT 3121 Internal medicine Microbiology 03 medical and health sciences Bacteroides vulgatus2 medicine Genetic predisposition Microbiome Seroconversion 030304 developmental biology Autoimmune disease Type 1 diabetes IDENTIFICATION VULGATUS biology.organism_classification medicine.disease Immunology PRONE RAT 3111 Biomedicine INFLAMMATORY-BOWEL-DISEASE |
| Zdroj: | Frontiers in Microbiology Frontiers in Microbiology, Vol 5 (2014) |
| ISSN: | 1664-302X |
| Popis: | The incidence of the autoimmune disease, type 1 diabetes (T1D), has increased dramatically over the last half century in many developed countries and is particularly high in Finland and other Nordic countries. Along with genetic predisposition, environmental factors are thought to play a critical role in this increase. As with other autoimmune diseases, the gut microbiome is thought to play a potential role in controlling progression to T1D in children with high genetic risk, but we know little about how the gut microbiome develops in children with high genetic risk for T1D. In this study, the early development of the gut microbiomes of 76 children at high genetic risk for T1D was determined using high-throughput 16S rRNA gene sequencing. Stool samples from children born in the same hospital in Turku, Finland were collected at monthly intervals beginning at 4-6 months after birth until 2.2 years of age. Of those 76 children, 29 seroconverted to T1D-related autoimmunity (cases) including 22 who later developed T1D, the remaining 47 subjects remained healthy (controls). While several significant compositional differences in low abundant species prior to seroconversion were found, one highly abundant group composed of two closely related species, Bacteroides dorei and Bacteroides vulgatus, was significantly higher in cases compared to controls prior to seroconversion. Metagenomic sequencing of samples high in the abundance of the B. dorei/vulgatus group before seroconversion, as well as longer 16S rRNA sequencing identified this group as Bacteroides dorei. The abundance of B. dorei peaked at 7.6 months in cases, over 8 months prior to the appearance of the first islet autoantibody, suggesting that early changes in the microbiome may be useful for predicting T1D autoimmunity in genetically susceptible infants. The cause of increased B. dorei abundance in cases is not known but its timing appears to coincide with the introduction of solid food. publishedVersion |
| Databáze: | OpenAIRE |
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