Long-term HPV-specific immune response after one versus two and three doses of bivalent HPV vaccination in Dutch girls
| Autor: | Fiona R. M. van der Klis, Hester E. de Melker, Anne-Marie Buisman, Marjan J.M. Bogaard, Marij J. P. Welters, Hella Pasmans, Tessa M Schurink-van 't Klooster, Sjoerd H. van der Burg, Debbie M. van Rooijen |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_treatment
T-Lymphocytes Antibody Affinity Antibodies Viral 0302 clinical medicine Medicine 030212 general & internal medicine Netherlands B-Lymphocytes Human papillomavirus 16 Vaccines biology Human papillomavirus 18 Vaccination Hpv vaccination Acquired immune system Infectious Diseases Cytokine Molecular Medicine Cytokines Female Antibody HPV Adolescent 030231 tropical medicine Immunology B-cells Bivalent (genetics) Antibodies 03 medical and health sciences Young Adult Immune system Humans Avidity Papillomavirus Vaccines Immunization Schedule General Veterinary General Immunology and Microbiology business.industry T-cells Papillomavirus Infections Public Health Environmental and Occupational Health Antibodies Neutralizing Immunoglobulin A Immunoglobulin G biology.protein business Immunologic Memory |
| Zdroj: | Vaccine, 37(49), 7280-7288 |
| ISSN: | 7280-7288 |
| Popis: | Background In view of further reduction of HPV vaccination schedules, gaining more insight into humoral and cellular immune responses after a single HPV vaccine is of great interest. Therefore, these responses were evaluated after different doses of the bivalent (2v) HPV-vaccine in girls. Methods Blood was collected yearly up to seven years post-vaccination with one-, two- or three-doses of the 2vHPV vaccine (N = 890). HPV-type-specific IgG and IgA-antibody levels, IgG-isotypes and avidity indexes were measured by a virus-like-particle-based multiplex-immuno-assay for two vaccine and five non-vaccine HPV types. HPV-type-specific memory B-cell numbers- and T-cell cytokine responses were determined in a subpopulation. Results HPV-type-specific antibody concentrations were significantly lower in one- than in two- and three-dose vaccinated girls but remained stable over seven years. The lower antibody response coincided with reduced HPV-type-specific B- and T-cell responses. There were no differences in both the IgG subtypes and the avidity of the HPV16-specific antibodies between the groups. Conclusions One-dose of the 2vHPV vaccine is immunogenic, but results in less B- and T-cell memory and considerable lower antibody responses when compared with more doses. Therefore, at least of some of girls receiving the one-dose of the vaccination might be at higher risk for waning immunity to HPV in the long-term. |
| Databáze: | OpenAIRE |
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