Cranberry (poly)phenol metabolites correlate with improvements in vascular function: A double-blind, randomized, controlled, dose-response, crossover study
| Autor: | Timon Weber, Albert Boeres, Rodrigo P. Feliciano, Ana Rodriguez-Mateos, M. Rita Ventura, Cláudia N. Santos, Christian Heiss |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male Blood Pressure Pulse Wave Analysis 03 medical and health sciences chemistry.chemical_compound food Double-Blind Method Caffeic acid Phenol Humans Phenols Food science Pulse wave velocity food.beverage 030109 nutrition & dietetics Chromatography Cross-Over Studies Dose-Response Relationship Drug CRANBERRY JUICE Polyphenols Crossover study Fruit and Vegetable Juices Vasodilation 030104 developmental biology Blood pressure Vaccinium macrocarpon chemistry Endothelium Vascular Vascular function Food Science Biotechnology |
| Zdroj: | Rodriguez-Mateos, A, Feliciano, R P, Boeres, A, Weber, T, Dos Santos, C N, Ventura, M R & Heiss, C 2016, ' Cranberry (poly)phenol metabolites correlate with improvements in vascular function : A double-blind, randomized, controlled, dose-response, crossover study ', Molecular Nutrition & Food Research, vol. 60, no. 10, pp. 2130-2140 . https://doi.org/10.1002/mnfr.201600250 |
| ISSN: | 1613-4133 |
| Popis: | SCOPE: Cranberries are rich in potentially bioactive (poly)phenols. The aim of this paper was to investigate whether cranberry juice intake can improve vascular function in healthy men in a dose- and time-dependent manner, and to understand which of the circulating (poly)phenol metabolites correlate with vascular effects.METHODS AND RESULTS: A double-blind randomized controlled crossover trial was conducted in ten healthy males. Flow-mediated dilation (FMD), blood pressure, pulse wave velocity and augmentation index were investigated at baseline, 1, 2, 4, 6, and 8 h post-consumption of cranberry juices containing 409, 787, 1238, 1534, and 1910 mg of total cranberry (poly)phenols (TP), and a control drink. Plasma (poly)phenol metabolites were analyzed by UPLC-Q-TOF MS using authentic standards. We observed dose-dependent increases in FMD at 1, 2, 4, 6, and 8 h with a peak at 4 h and maximal effects with juice containing 1238 mg TP. A total of 60 metabolites were quantified in plasma after cranberry consumption. Twelve (poly)phenol metabolites significantly correlated with the increases in FMD, including ferulic and caffeic acid sulfates, quercetin-3-O-ß-D-glucuronide and a γ-valerolactone sulfate.CONCLUSION: (Poly)phenols in cranberry juice can improve vascular function in healthy males and this is linked to the presence of specific newly identified plasma metabolites. |
| Databáze: | OpenAIRE |
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