An Evaluation of Flurbiprofen, Aspirin, and Placebo in Postoperative Oral Surgery Pain
| Autor: | Lawrence R. Selinger, William T. Beaver, Stanley K. Rosenmertz, Christine C. Yorio, James A. Forbes |
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| Rok vydání: | 1989 |
| Předmět: |
Adult
Male Analgesic effect medicine.medical_specialty Time Factors Adolescent Dose Oral surgery Postoperative pain Flurbiprofen Placebo Random Allocation Double-Blind Method medicine Humans Pharmacology (medical) Adverse effect Clinical Trials as Topic Mouth Pain Postoperative Aspirin Dose-Response Relationship Drug business.industry musculoskeletal system Surgery Evaluation Studies as Topic Anesthesia Female lipids (amino acids peptides and proteins) Propionates business medicine.drug |
| Zdroj: | Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 9:66-73 |
| ISSN: | 0277-0008 |
| DOI: | 10.1002/j.1875-9114.1989.tb04105.x |
| Popis: | One hundred sixty-four outpatients with postoperative pain after the removal of impacted third molars were randomly assigned, on a double-blind basis, to receive oral doses of flurbiprofen 25, 50, or 100 mg; aspirin 600 mg; or placebo. Using a self-rating record, subjects rated their pain and its relief hourly for 8 hours after medicating. Estimates of sum of pain differences (SPID), peak pain intensity difference (PID), total relief, peak relief, and hours of 50% relief were derived from these subjective reports. All active medications were significantly superior to placebo. Analgesia was similar for flurbiprofen 25 mg and aspirin 600 mg. Flurbiprofen 50 and 100 mg were significantly superior to aspirin for every measure of analgesia except peak PID. There was a significant dose-response regression between flurbiprofen 25 mg and both of the higher dosages. Flurbiprofen 50 and 100 mg did not differ significantly, suggesting a plateau in flurbiprofen's analgesia. The analgesic effect of flurbiprofen was significant by hour 1 and persisted for 8 hours. The frequency of adverse effects was similar for the active medications. |
| Databáze: | OpenAIRE |
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