Hypoxia-inducible factor 1 and related gene products in anaesthetic-induced preconditioning
| Autor: | Ragnar Huhn, Stefanie Hieber, Nina C. Weber, Benedikt Preckel, Markus W. Hollmann |
|---|---|
| Přispěvatelé: | Anesthesiology, Amsterdam Cardiovascular Sciences, Amsterdam institute for Infection and Immunity |
| Rok vydání: | 2009 |
| Předmět: |
Regulation of gene expression
Cardioprotection Hypoxia-Inducible Factor 1 business.industry Hypoxia (medical) Pharmacology Anesthesiology and Pain Medicine Gene Expression Regulation Downregulation and upregulation Isoflurane Anesthesia medicine Animals Humans medicine.symptom Signal transduction Hypoxia business Transcription factor Anesthetics Signal Transduction medicine.drug |
| Zdroj: | European journal of anaesthesiology, 26(3), 201-206. Wolters Kluwer Health |
| ISSN: | 0265-0215 |
| Popis: | Volatile anaesthetics induce early and late preconditioning in several organs, including the heart. This phenomenon is of particular interest in the clinical setting to reduce infarct size and to elicit adaptive functions of the heart. One possible mechanism of anaesthetic-induced preconditioning is the activation of the transcription factor hypoxia-inducible factor 1 alpha (HIF-1 alpha) and its target gene responses. It was shown that pharmacological activation of the hypoxia-inducible factor 1 alpha pathway is organ protective, and recent studies demonstrated that isoflurane and xenon lead to hypoxia-inducible factor 1 alpha upregulation, which is related to the preconditioning effect of the inhalational anaesthetics. A better understanding of the molecular mechanisms that mediate cardioprotection by volatile anaesthetics might help to introduce specific applications of these substances for organ-protective purposes in patients with cardiovascular diseases. Eur J Anaesthesiol 26:201-206 (C) 2009 European Society of Anaesthesiology |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|