Low value of second-look endoscopy for detecting residual colorectal cancer after endoscopic removal
| Autor: | E. M. Witteman, Marc A.W.M. van Milligen de Wit, Rogier de Ridder, Marco J. Bruno, Wouter H. de Vos tot Nederveen Cappel, Pieter J.C. ter Borg, Evelien Dekker, Dirk Jan Bac, Monique E. van Leerdam, Stephan Schmittgens, Thjon J. Tang, Ludger S.M. Epping Stippel, Tanya M. Bisseling, Ramon-Michel Schreuder, Frank P. Vleggaar, Anke M. Zonneveld, Ruud W.M. Schrauwen, Ivonne Leeuwenburgh, Leon M G Moons, Yasser A. Alderlieste, Niels van Lelyveld, Muhammed Hadithi, Rob M. E. Slangen, Frank ter Borg, Renzo P. Veenstra, Rolf van Roermund, Zoe Post, Arjun D. Koch, P. Honkoop, Kim M. Gijsbers |
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| Přispěvatelé: | Gastroenterology & Hepatology, Gastroenterology and Hepatology, AGEM - Re-generation and cancer of the digestive system, CCA - Imaging and biomarkers, APH - Quality of Care, Interne Geneeskunde, MUMC+: MA Maag Darm Lever (9), RS: FHML non-thematic output |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Neoplasm Residual recurrence RESECTION Colorectal cancer Colonoscopy SDG 3 - Good Health and Well-being Biopsy Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14] medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Prospective cohort study medicine.diagnostic_test business.industry Gastroenterology LYMPH-NODE METASTASIS Cancer medicine.disease Confidence interval Endoscopy Clinical trial RISK-FACTORS Radiology Colorectal Neoplasms business |
| Zdroj: | Gastrointestinal Endoscopy, 92, 166-172 Gastrointestinal Endoscopy, 92(1), 166-172. Mosby Inc. Gastrointestinal endoscopy, 92(1), 166-172. Mosby Inc. Gastrointestinal Endoscopy, 92(1), 166-172. MOSBY-ELSEVIER Gastrointestinal Endoscopy, 92, 1, pp. 166-172 |
| ISSN: | 1097-6779 0016-5107 |
| Popis: | Contains fulltext : 225271.pdf (Publisher’s version ) (Closed access) BACKGROUND AND AIMS: Endoscopic resection is often feasible for submucosal invasive colorectal cancers (T1 CRCs) and usually judged as complete. If histology casts doubt on the radicality of resection margins, adjuvant surgical resection is advised, although residual intramural cancer is found in only 5% to 15% of patients. We assessed the sensitivity of biopsy specimens from the resection area for residual intramural cancer as a potential tool to estimate the preoperative risk of residual intramural cancer in patients without risk factors for lymph node metastasis (LNM). METHODS: In this multicenter prospective cohort study, patients with complete endoscopic resection of T1 CRC, scheduled for adjuvant resection due to pathologically unclear resection margins, but absent risk factors for LNM, were asked to consent to second-look endoscopy with biopsies. The results were compared with the pathology results of the surgical resection specimen (criterion standard). RESULTS: One hundred three patients were included. In total, 85% of resected lesions were unexpectedly malignant, and 45% were removed using a piecemeal resection technique. Sixty-four adjuvant surgical resections and 39 local full-thickness resections were performed. Residual intramural cancer was found in 7 patients (6.8%). Two of these patients had cancer in second-look biopsy specimens, resulting in a sensitivity of 28% (95% confidence interval |
| Databáze: | OpenAIRE |
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