Changes of immunological markers after autologous peripheral blood stem cell transplantation
| Autor: | Kazuyuki Yamaguchi, Yuji Kishimoto, Noriaki Matsumoto, Shirou Fukuhara, Tetsuji Ohtani, Shosaku Nomura, Toshiki Shimizu, Hiroyuki Kitajima, Kaoruko Katsura |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Lung Neoplasms Lymphoma medicine.medical_treatment T-Lymphocytes Antigens CD34 Transplantation Autologous Immunophenotyping Immune system Internal medicine medicine Cytotoxic T cell Humans Lung cancer Aged Bone Marrow Transplantation Hematology business.industry Hematopoietic Stem Cell Transplantation General Medicine Middle Aged medicine.disease Cytokine Oncology Immunology Cytokines Female Stem cell business CD8 Biomarkers |
| Zdroj: | Journal of cancer research and clinical oncology. 124(11) |
| ISSN: | 0171-5216 |
| Popis: | Recently high-dose chemotherapy with peripheral blood stem cell transplantation (PBSCT) has become an important treatment for hematological and solid tumors. Methods: Immunological parameters were examined before and after PBSCT in 9 patients with lung cancer and 13 patients with malignant lymphoma. Findings were compared with those for bone marrow transplantation (BMT). Peripheral blood cells were analyzed for phenotype and the levels of cytokines and soluble factors were measured. Results: After PBSCT, activated T cells (CD3+HLA-DR+ cells, CD8+HLA-DR+ cells) and suppressor/cytotoxic T cells (CD8+CD11b− cells) were significantly higher in the patients with lung cancer than in those with malignant lymphoma. Serum levels of interleukin-4 and soluble interleukin-2 receptor were also significantly higher in the patients with lung cancer than in those with lymphoma. On the other hand, the serum levels of interferon γ, tumor necrosis factor α, interleukin-6, soluble human leukocyte antigen class 1, and soluble thrombomodulin were significantly increased after bone marrow transplantation. The transfused peripheral stem cells of lung cancer and lymphoma patients had a similar number of granulocyte/macrophage-colony-forming units, but lung cancer patients had significantly more CD34-positive cells. Conclusion: By reinfusing large numbers of autologous immune cells, PBSCT may accelerate immune reconstitution, with T cells being likely to have a marked therapeutic potential. The changes after PBSCT were greater in patients with lung cancer than in lymphoma patients. These blood cells are potent mediators of anticancer activity and could play an important role in the elimination of autologous malignant cells. |
| Databáze: | OpenAIRE |
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