Selective Serotonin Reuptake Inhibitors and the Risk of Osseointegrated Implant Failure
| Autor: | S. Abi Nader, E. Rastikerdar, Belinda Nicolau, Khadijeh Al-Abedalla, Nach G. Daniel, Faleh Tamimi, Xixi Wu |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Adolescent Dentistry behavioral disciplines and activities Osseointegration Medication Adherence Cohort Studies Dental Materials Young Adult Risk Factors mental disorders medicine Humans Dental Restoration Failure General Dentistry Aged Proportional Hazards Models Retrospective Studies Aged 80 and over Dental Implants Titanium Proportional hazards model business.industry Smoking digestive oral and skin physiology Hazard ratio Implant failure Research Reports Retrospective cohort study Bone fracture Middle Aged medicine.disease Treatment Outcome Dental Prosthesis Design Female Implant business Selective Serotonin Reuptake Inhibitors Follow-Up Studies Cohort study |
| Zdroj: | Journal of Dental Research. 93:1054-1061 |
| ISSN: | 1544-0591 0022-0345 |
| DOI: | 10.1177/0022034514549378 |
| Popis: | Selective serotonin reuptake inhibitors (SSRIs), the most widely used drugs for the treatment of depression, have been reported to reduce bone formation and increase the risk of bone fracture. Since osseointegration is influenced by bone metabolism, this study aimed to investigate the association between SSRIs and the risk of failures in osseointegrated implants. This retrospective cohort study was conducted on patients treated with dental implants from January 2007 to January 2013. A total of 916 dental implants in 490 patients (94 implants on 51 patients using SSRIs) were used to estimate the risk of failure associated with the use of SSRIs. Data analysis involved Cox proportional hazards, generalized estimating equation models, multilevel mixed effects parametric survival analysis, and Kaplan-Meier analysis. After 3 to 67 mo of follow-up, 38 dental implants failed and 784 succeeded in the nonusers group, while 10 failed and 84 succeeded in the SSRI-users group. The main limitation of this retrospective study was that drug compliance dose and treatment period could not be acquired from the files of the patients. The primary outcome was that compared with nonusers of SSRIs, SSRI usage was associated with an increased risk of dental implants failure (hazard ratio, 6.28; 95% confidence interval, 1.25-31.61; p = .03). The failure rates were 4.6% for SSRI nonusers and 10.6% for SSRI users. The secondary outcomes were that small implant diameters (≤4 mm; p = .02) and smoking habits ( p = .01) also seemed to be associated with higher risk of implant failure. Our findings indicate that treatment with SSRIs is associated with an increased failure risk of osseointegrated implants, which might suggest a careful surgical treatment planning for SSRI users. |
| Databáze: | OpenAIRE |
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