OnabotulinumtoxinA in chronic migraine: predictors of response. A prospective multicentre descriptive study
| Autor: | M. Huerta, Patricia Pozo-Rosich, Marta Torres-Ferrus, J. García-Alhama, N. Hernández-Beltrán, A. Gago, L.C. Álvaro, C. González-Oria, R. Belvís, M.J. Monzón, Clara Domínguez, M. Gallego, S. Santos, V. Medrano, Yago Leira, Rogelio Leira, G. Latorre, C. Jurado-Cobo |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Migraine Disorders Disease 03 medical and health sciences 0302 clinical medicine Chronic Migraine Internal medicine Outcome Assessment Health Care Humans Medicine Medical history Prospective Studies 030212 general & internal medicine Botulinum Toxins Type A Adverse effect business.industry Odds ratio Middle Aged Response to treatment Confidence interval Neuromuscular Agents Neurology Chronic Disease Female Neurology (clinical) Headaches medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | European Journal of Neurology. 25:411-416 |
| ISSN: | 1468-1331 1351-5101 |
| Popis: | Background and purpose: OnabotulinumtoxinA is a treatment specifically approved for the prophylaxis of chronic migraine in adults. The aim of this study was to assess the effectiveness of OnabotulinumtoxinA in chronic migraine after 1 year of treatment in a real-life setting and to identify clinical predictors of outcome. Methods: We designed a prospective multicentre study performed in 13 hospitals in Spain. Patients underwent a complete medical history and examination. They were treated with OnabotulinumtoxinA every 12 weeks for 1 year. Data about outcome, adverse events, abortive medication use, emergency room use and disability were collected at 3 and 12 months. Results: A total of 725 subjects completed the study. At 12 months, 79.3% showed >50% reduction in number of headaches per month and 94.9% reported no adverse events. Unilaterality of pain, fewer days of disability per month and milder headache at baseline were correlated with good outcome. Duration of disease |
| Databáze: | OpenAIRE |
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