Effect of Thrombomodulin Alfa on Disseminated Intravascular Coagulation in Patients with Lung Cancer
| Autor: | Hideyuki Satoh, Shingo Tokita, Kenya Koyama, Hiroyoshi Watanabe, Masamitsu Tatewaki, Kumiya Sugiyama, Ryosuke Souma, Tomoshige Wakayama, Hirokuni Hirata, Kentaro Nakano, Hiroyuki Masuda, Yasutsugu Fukushima, Naruo Yoshida, Takayoshi Fujimatsu, Hajime Arifuku |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Lung Neoplasms Thrombomodulin 030204 cardiovascular system & hematology Significant negative correlation Gastroenterology 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Internal medicine Internal Medicine medicine Humans Platelet In patient Lung cancer Aged Disseminated intravascular coagulation business.industry Mortality rate Significant difference General Medicine Disseminated Intravascular Coagulation Middle Aged medicine.disease Blood Coagulation Factors lung cancer Thrombomodulin Alfa 030220 oncology & carcinogenesis Original Article Female business thrombomodulin alfa circulatory and respiratory physiology |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| Popis: | Objective The mortality rate due to disseminated intravascular coagulation (DIC) is higher in patients with lung cancer than in those without. We examined the effect of treatment with thrombomodulin alfa (TM-α) for DIC in lung cancer patients. Methods Subjects were 57 patients with DIC (43 men, 14 women; mean age, 71.7 years), comprising 31 with lung cancer and 26 without. DIC patients with or without lung cancer did not differ significantly in their background characteristics. Results No significant difference was noted in the mortality rate between patients with lung cancer (61.3%) and those without (57.7%). However, the dose of TM-α was higher for survivors with lung cancer than for non-survivors (473.1 U/kg/day vs. 380.6 U/kg/day; p |
| Databáze: | OpenAIRE |
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