Two distinct types of eye-head coupling in freely moving mice
| Autor: | Arne F. Meyer, Jasper Poort, John O'Keefe |
|---|---|
| Přispěvatelé: | Poort, Jasper [0000-0001-6306-4042], Apollo - University of Cambridge Repository |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine Neuroinformatics head movement vision Eye Movements genetic structures Movement pupil Biology gaze General Biochemistry Genetics and Molecular Biology Article Young Adult natural behavior Mice 03 medical and health sciences 0302 clinical medicine Humans Animals Head restraint eye movement Vision Ocular 030304 developmental biology Vestibular system 0303 health sciences oculomotor system vestibular system Eye movement Gaze eye diseases Saccadic masking Visual field Mice Inbred C57BL 030104 developmental biology Head Movements Fixation (visual) Saccade Eye tracking Female sense organs General Agricultural and Biological Sciences Psychology Head Neuroscience Psychomotor Performance 030217 neurology & neurosurgery |
| Zdroj: | Current Biology, 30, 2116-2130 Current Biology, 30, 11, pp. 2116-2130 Current Biology |
| ISSN: | 0960-9822 |
| Popis: | Summary Animals actively interact with their environment to gather sensory information. There is conflicting evidence about how mice use vision to sample their environment. During head restraint, mice make rapid eye movements coupled between the eyes, similar to conjugate saccadic eye movements in humans. However, when mice are free to move their heads, eye movements are more complex and often non-conjugate, with the eyes moving in opposite directions. We combined head and eye tracking in freely moving mice and found both observations are explained by two eye-head coupling types, associated with vestibular mechanisms. The first type comprised non-conjugate eye movements, which compensate for head tilt changes to maintain a similar visual field relative to the horizontal ground plane. The second type of eye movements was conjugate and coupled to head yaw rotation to produce a “saccade and fixate” gaze pattern. During head-initiated saccades, the eyes moved together in the head direction but during subsequent fixation moved in the opposite direction to the head to compensate for head rotation. This saccade and fixate pattern is similar to humans who use eye movements (with or without head movement) to rapidly shift gaze but in mice relies on combined head and eye movements. Both couplings were maintained during social interactions and visually guided object tracking. Even in head-restrained mice, eye movements were invariably associated with attempted head motion. Our results reveal that mice combine head and eye movements to sample their environment and highlight similarities and differences between eye movements in mice and humans. Highlights • Head and eye tracking in freely moving mice reveals two types of eye-head coupling • Eye coupling to head tilt aligns gaze to the horizontal plane • Eye coupling to head yaw rotation produces a “saccade and fixate” gaze pattern • Eye movements in head-restrained mice are related to attempted head rotation Meyer et al. track head and eyes in freely moving mice and find two distinct types of eye-head coupling. Eye coupling to head tilt aligns gaze to the horizontal plane, while eye coupling to yaw head rotation produces a “saccade and fixate” gaze pattern. Also in head-restrained mice, eye movements are linked to attempted head rotation. |
| Databáze: | OpenAIRE |
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