Deep brain stimulation of the subthalamic nucleus in obsessive-compulsives disorders: long-term follow-up of an open, prospective, observational cohort
| Autor: | Thierry Bougerol, Jérôme Yelnik, Luc Mallet, Alim-Louis Benabid, Sara Fernandez Vidal, Olivier David, Stephan Chabardes, Paul Krack, Mircea Polosan, Brigitte Piallat, Eric Seigneuret |
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| Přispěvatelé: | Clinatec - Centre de recherche biomédicale Edmond J.Safra (SCLIN), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), [GIN] Grenoble Institut des Neurosciences (GIN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Bern University Hospital [Berne] (Inselspital), Centre Hospitalier Universitaire [Grenoble] (CHU), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CHU Henri Mondor, University of Geneva [Switzerland], Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CHU Henri Mondor [Créteil], Université de Genève = University of Geneva (UNIGE) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Obsessive-Compulsive Disorder medicine.medical_treatment [SDV]Life Sciences [q-bio] Deep Brain Stimulation Anxiety Severity of Illness Index Cohort Studies ddc:616.89 0302 clinical medicine Quality of life Basal ganglia Prospective Studies Prospective cohort study 0303 health sciences Anxiety/etiology Middle Aged 3. Good health Psychiatry and Mental health Subthalamic nucleus Mania Treatment Outcome Cohort Female Cohort study Adult medicine.medical_specialty Deep brain stimulation Neurosurgery 610 Medicine & health Deep Brain Stimulation/adverse effects behavioral disciplines and activities 03 medical and health sciences Subthalamic Nucleus Internal medicine Deep Brain Stimulation/methods Severity of illness mental disorders medicine Humans 030304 developmental biology business.industry Mania/etiology nervous system Obsessive-Compulsive Disorder/therapy Surgery Neurology (clinical) business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Chabardes, Stephan; Krack, Paul; Piallat, Brigitte; Bougerol, Thierry; Seigneuret, Eric; Yelnik, Jerome; Fernandez Vidal, Sara; David, Olivier; Mallet, Luc; Benabid, Alim-Louis; Polosan, Mircea (2020). Deep brain stimulation of the subthalamic nucleus in obsessive-compulsives disorders: long-term follow-up of an open, prospective, observational cohort. Journal of neurology, neurosurgery, and psychiatry, 91(12), pp. 1349-1356. BMJ Publishing Group 10.1136/jnnp-2020-323421 Journal of Neurology, Neurosurgery, and Psychiatry, Vol. 91, No 12 (2020) pp. 1349-1356 Journal of Neurology, Neurosurgery, and Psychiatry Journal of Neurology, Neurosurgery and Psychiatry Journal of Neurology, Neurosurgery and Psychiatry, BMJ Publishing Group, 2020, 91 (12), pp.1349-1356. ⟨10.1136/jnnp-2020-323421⟩ Journal of Neurology, Neurosurgery and Psychiatry, 2020, 91 (12), pp.1349-1356. ⟨10.1136/jnnp-2020-323421⟩ |
| ISSN: | 0022-3050 1468-330X |
| DOI: | 10.1136/jnnp-2020-323421 |
| Popis: | BackgroundObsessive–compulsive disorder (OCD) is a major cause of disability in western country and responsible for severe impairment of quality of life. About 10% of patients present with severe OCD symptoms and require innovative treatment such as deep brain stimulation (DBS). Among possible targets, the non-motor subthalamic nucleus (STN) is a key node of the basal ganglia circuitry, strongly connected to limbic cortical areas known to be involved in OCD.MethodWe analysed, in a prospective, observational, monocentric, open label cohort, the effect of chronic non-motor STN-DBS in 19 patients with treatment-resistant OCD consecutively operated in a single centre. Severity of OCD was evaluated using the Yale and Brown Obsessive–Compulsive Scale (YBOCS). YBOCS scores at 6, 12 and 24 months postoperatively were compared with baseline. Responders were defined by >35% improvement of YBOCS scores. Global Assessment Functioning (GAF) scale was used to evaluate the impact of improvement.ResultsAt a 24-month follow-up, the mean YBOCS score improved by 53.4% from 33.3±3.5 to 15.8±9.1 (95% CI 11.2–20.4; pConclusionChronic DBS of the non-motor STN is an effective and relatively safe procedure to treat severe OCD resistant to conventional management. |
| Databáze: | OpenAIRE |
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