Improvement of urinary tract symptoms and quality of life in benign prostate hyperplasia patients associated with consumption of a newly developed whole tomato-based food supplement: a phase II prospective, randomized double-blinded, placebo-controlled study

Autor: Pier Giorgio Natali, Paola Vitaglione, Manuela Iezzi, Giuseppe Carrieri, Beppe Calò, Giovanni Silecchia, Vincenzo Fogliano, Alessia Lamolinara, Stefano Iacobelli, Ugo Falagario, Luigi Cormio, Mauro Piantelli
Přispěvatelé: Cormio, Luigi, Calò, Beppe, Falagario, Ugo, Iezzi, Manuela, Lamolinara, Alessia, Vitaglione, Paola, Silecchia, Giovanni, Carrieri, Giuseppe, Fogliano, Vincenzo, Iacobelli, Stefano, Giorgio Natali, Pier, Piantelli, Mauro
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
medicine.medical_specialty
Olive polyphenol
Urinary system
Food supplement
Placebo-controlled study
Prostatic Hyperplasia
lcsh:Medicine
Placebo
General Biochemistry
Genetics and Molecular Biology
Tomato
03 medical and health sciences
0302 clinical medicine
Quality of life
Solanum lycopersicum
Lower urinary tract symptoms
Benign prostate hyperplasia
Internal medicine
medicine
Lower urinary tract symptom
Humans
Prospective Studies
Lycopersicon esculentum
Urinary Tract
VLAG
Dietary Supplement
Aged
030109 nutrition & dietetics
Hyperplasia
business.industry
Research
lcsh:R
General Medicine
medicine.disease
Regimen
Prospective Studie
Food Quality and Design
Treatment Outcome
030220 oncology & carcinogenesis
Dietary Supplements
Quality of Life
Olive polyphenols
Urologic disease
business
Human
Zdroj: Journal of Translational Medicine
Journal of Translational Medicine, 19(1)
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-8 (2021)
Journal of Translational Medicine 19 (2021) 1
ISSN: 1479-5876
Popis: Background Benign prostatic hyperplasia (BPH) is the most common urologic disease among elderly men. The diagnosis of BPH is usually driven by lower urinary tract symptoms (LUTS) that can significantly affect patients’ quality of life. This phase II prospective, randomized double-blinded, placebo-controlled study aimed to determine the efficacy and safety of a novel whole tomato-based food supplement on LUTS of patients diagnosed with BPH. Methods Forty consecutive patients with histologically proved BPH were randomized 1:1 to receive daily for 2 months a sachet (5 g) of a newly developed whole tomato food supplement (WTFS) (treatment = Group A) or placebo (Group B). Patients were asked to fill the International Prostatic Symptom Score (IPSS) questionnaire before and after treatment. Results All but 1 patient in Group B successfully completed the scheduled regimen. No side effects were recorded. Unlike placebo, treatment significantly reduced (P Conclusions The new WTFS may represent a valid option for the treatment of symptomatic BPH patients. Unlike pharmacological treatments, the supplement is side effects free and highly accepted among patients.
Databáze: OpenAIRE
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