Whole-lesion apparent diffusion coefficient (ADC) metrics as a marker of breast tumour characterization—comparison between ADC value and ADC entropy
| Autor: | Dimitrios Priovolos, Abraham Ghiatas, Konstantia Veliou, Alexandra Christou, Haralambos Bougias |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty Volume of interest Breast Neoplasms Sensitivity and Specificity 030218 nuclear medicine & medical imaging Lesion 03 medical and health sciences 0302 clinical medicine medicine Humans Effective diffusion coefficient Breast MRI Radiology Nuclear Medicine and imaging Breast Prospective Studies Aged Full Paper medicine.diagnostic_test business.industry Breast tumours Reproducibility of Results General Medicine Middle Aged Magnetic Resonance Imaging body regions 030220 oncology & carcinogenesis Female Radiology medicine.symptom Nuclear medicine business |
| Zdroj: | The British Journal of Radiology. 89:20160304 |
| ISSN: | 1748-880X 0007-1285 |
| Popis: | To prospectively assess the role of whole-lesion apparent diffusion coefficient (ADC) metrics in the characterization of breast tumours by comparing ADC value with ADC entropy.49 patients with 53 breast lesions underwent phased-array breast coil 1.5-T MRI. Two radiologists experienced in breast MRI, blinded to the final diagnosis, reviewed the ADC maps and placed a volume of interest on all slices including each lesion on the ADC map to obtain whole-lesion mean ADC value and ADC entropy. The mean ADC value and ADC entropy in benign and malignant lesions were compared by the Mann-Whitney U-test. Receiver-operating characteristic analysis was performed to assess the sensitivity and specificity of the two variables in the characterization of the breast lesions.The benign (n = 19) and malignant lesions (n = 34) had mean diameters of 20.8 mm (10.1-31.5 mm) and 26.4 mm (10.5-42.3 mm), respectively. The mean ADC value of the malignant lesions was significantly lower than that of the benign ones (0.87 × 10Whole-lesion mean ADC could be a helpful index in the characterization of suspicious breast lesions, with higher sensitivity and specificity than ADC entropy. Advances in knowledge: Two separate parameters of the whole-lesion histogram were compared for their diagnostic accuracy in characterizing breast lesions. Mean ADC was found to be able to characterize breast lesions, whereas entropy proved to be unable to differentiate benign from malignant breast lesions. It is, however, likely that entropy may distinguish these two groups if a larger cohort were used, or the fact that this may be influenced by the molecular subtypes of breast cancers included. |
| Databáze: | OpenAIRE |
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