Severity of respiratory failure and computed chest tomography in acute COVID-19 correlates with pulmonary function and respiratory symptoms after infection with SARS-CoV-2: An observational longitudinal study over 12 months

Autor: Florian Kurth, Florian Alius, Martin Witzenrath, Christoph Ruwwe-Gloesenkamp, Elisa T Helbig, Norbert Suttorp, Felix Doellinger, Thomas Zoller, Hans-Jakob Meyer, Daniel Grund, Charlotte Thibeault, Lena J Lippert, Raphaela Maria Ring, Philipp Knape, Fridolin Steinbeis, Mirja Mittermaier, Leif E. Sander, Bettina Temmesfeld-Wollbrueck, Tobias Penzkofer
Rok vydání: 2021
Předmět:
Male
Longitudinal study
medicine.medical_treatment
Vital Capacity
Disease
Severity of Illness Index
Pulmonary function testing
Quality of life
Forced Expiratory Volume
Surveys and Questionnaires
Longitudinal Studies
Respiratory system
Lung
Original Research
Long-COVID
Middle Aged
Respiratory Function Tests
Hospitalization
Post-COVID
Pulmonary outcome
Female
Respiratory Insufficiency
Pulmonary and Respiratory Medicine
Adult
medicine.medical_specialty
Pulmonary function
Post-acute COVID
Extracorporeal Membrane Oxygenation
Post-Acute COVID-19 Syndrome
Internal medicine
medicine
Humans
Aged
Mechanical ventilation
business.industry
SARS-CoV-2
Total Lung Capacity
Oxygen Inhalation Therapy
COVID-19
Recovery of Function
Pneumonia
Respiration
Artificial
Clinical trial
Respiratory failure
Pulmonary Diffusing Capacity
Pulmonary sequelae
business
Tomography
X-Ray Computed
Pulmonary restriction
Zdroj: Respiratory Medicine
ISSN: 1532-3064
Popis: Introduction Prospective and longitudinal data on pulmonary injury over one year after acute coronavirus disease 2019 (COVID-19) are sparse. We aim to determine reductions in pulmonary function and respiratory related quality of life up to 12 months after acute COVID-19. Methods Patients with acute COVID-19 were enrolled into an ongoing single-centre, prospective observational study and prospectively examined 6 weeks, 3, 6 and 12 months after onset of COVID-19 symptoms. Chest CT-scans, pulmonary function and symptoms assessed by St. Georges Respiratory Questionnaire were used to evaluate respiratory limitations. Patients were stratified according to severity of acute COVID-19. Results Median age of all patients was 57 years, 37.8% were female. Higher age, male sex and higher BMI were associated with acute-COVID-19 severity (p
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Databáze: OpenAIRE
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