| Autor: |
Brad Wouters, Michael Garrels, Myron I. Cybulsky, Victor H Ferreira, Krista M. Pace, Pouria Mashouri, Matthew Ierullo, Michael Brudno, Deepali Kumar, Andrzej Chruscinski, Atul Humar, Bernard Lam, Beata Majchrzak-Kita, Ilinca Lungu, Tony Mazzulli, Tamara Dus, Amit M. Oza, Trevor J. Pugh, Natalia Pinzon, Ilona Bahinskaya, Lawrence E. Heisler, Dorin Manase, Vathany Kulasingam, Sonika T. Humar, Paul M. Krzyzanowski, Terrance J.Y. Ku, Jianhua Zhang |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| DOI: |
10.1101/2020.07.21.20159053 |
| Popis: |
We screened three separate cohorts of healthcare workers for SARS-CoV-2 via nasopharyngeal swab PCR. A seroprevalence analysis using multiple assays was performed in a subgroup. The asymptomatic health care worker cohorts had a combined swap positivity rate of 29/5776 (0.50%, 95%CI 0.32-0.75) compared to the symptomatic cohort rate of 54/1597 (3.4%) (ratio of symptomatic to asymptomatic 6.8:1). Sequencing demonstrated several variants. The seroprevalence (n=996) was 1.4-3.4% depending on assay. Protein microarray analysis showed differing SARS-CoV-2 protein reactivities and helped define likely true positives vs. suspected false positives. Routine screening of asymptomatic health care workers helps identify a significant proportion of infections. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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