Ultra-structural study of the indomethacin-induced apoptosis and autophagy in rat gastric parietal cells

Autor:	Hoda M. Elsayed, Sahar M. Gebril, Usama M. Abdelaal, Asmaa N. Mohammad, Mahmoud R. Hussein, Kazuhide Higuchi, Eman E. Abu-Dief, Yuko Ito
Rok vydání:	2020
Předmět:	Male 0301 basic medicine Indomethacin Apoptosis Pathology and Forensic Medicine Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Parietal Cells Gastric Structural Biology Autophagy Gastric mucosa medicine Animals Chemistry Anti-Inflammatory Agents Non-Steroidal digestive oral and skin physiology food and beverages biochemical phenomena metabolism and nutrition digestive system diseases Rats 030104 developmental biology medicine.anatomical_structure Gastric Parietal Cells 030220 oncology & carcinogenesis Cancer research sense organs
Zdroj:	Ultrastructural Pathology. 44:300-313
ISSN:	1521-0758 0191-3123
DOI:	10.1080/01913123.2020.1772429
Popis:	IndomethacinWe established an animal model consisting of 35 adult male Sprague Dawley rats. The animals were divided into three groups, including; control (normal feeding), fasting, and indomethacin-treated groups. After treatment of 18-h fasting rats withIn normal feeding animals (control group), the gastricOur study indicates that IND treatment could induce gastropathy through time-dependent alterations in the autophagic and apoptotic machinery of PCs. Further studies are needed to examine the underlying molecular mechanisms.
Databáze:	OpenAIRE
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