Combined serum biomarkers in the noninvasive diagnosis of complicated parapneumonic effusions and empyema
| Autor: | Chi-Ming Chu, Chih-Ching Wu, Chih-Liang Wang, Pei-Chun Hsueh, Chia-Yin Chin, Chia-Yu Yang, Kuo-An Wu, Yu-Ching Liu, Li-Jane Shih |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Pleural effusion Taiwan Serum biomarker Lipocalin Sensitivity and Specificity Gastroenterology AZU1 Serology 03 medical and health sciences fluids and secretions 0302 clinical medicine Lipocalin-2 Internal medicine medicine Humans 030212 general & internal medicine NGAL Azurocidin 1 Empyema Pleural Aged Aged 80 and over lcsh:RC705-779 Calprotectin business.industry Area under the curve Pneumonia lcsh:Diseases of the respiratory system Middle Aged medicine.disease Empyema respiratory tract diseases Pleural Effusion ROC Curve 030228 respiratory system Area Under Curve Case-Control Studies BPI PPE Female business Leukocyte L1 Antigen Complex Biomarkers Research Article |
| Zdroj: | BMC Pulmonary Medicine, Vol 19, Iss 1, Pp 1-9 (2019) BMC Pulmonary Medicine |
| ISSN: | 1471-2466 |
| DOI: | 10.1186/s12890-019-0877-8 |
| Popis: | Background We previously demonstrated that the pleural levels of proteins (neutrophil gelatinase-associated lipocalin/NGAL, calprotectin, bactericidal permeability-increasing/BPI, azurocidin 1/AZU-1) were valuable markers for identifying complicated PPE (CPPE). Herein, this study was performed to evaluate whether these proteins are useful as serological markers for identifying CPPE and empyema. Methods A total of 137 participates were enrolled in this study. The levels of NGAL, calprotectin, BPI and AZU-1 were measured in serum and pleural fluid by enzyme-linked immunosorbent assay. We also characterized the diagnostic values of these markers between different groups. Results The serum levels of NGAL, calprotectin, and BPI in PPE patients were significantly higher than those in transudates, noninfectious exudates, and healthy controls. The area under the curve (AUC) values of NGAL, calprotectin, and BPI for distinguishing PPE from transudates or noninfectious exudates were around 0.861 to 0.953. In PPE group, serum NGAL and calprotectin levels were significantly elevated in patients with CPPE and empyema than in those with UPPE, whereas the serum BPI levels were similar between these two groups. In CPPE and empyema patients, the serum NGAL showed a positive correlation with the pleural fluid NGAL (r = 0.417, p |
| Databáze: | OpenAIRE |
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