Is there any relationship between serum sirtuin-1 level and neutrophil-lymphocyte ratio in hyperemesis gravidarum?
| Autor: | Yaprak Engin-Ustun, Muhammed Fevzi Polat, Ayşe Yeşim Göçmen, Mustafa Kara, Levent Seçkin, Nagihan Sari, Emel Kiyak Caglayan |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty Neutrophils medicine.medical_treatment Blood lipids Gastroenterology 03 medical and health sciences Hyperemesis gravidarum Leukocyte Count Young Adult 0302 clinical medicine Sirtuin 1 Pregnancy Internal medicine Hyperemesis Gravidarum medicine Humans Lymphocytes 030219 obstetrics & reproductive medicine medicine.diagnostic_test business.industry Insulin Case-control study Obstetrics and Gynecology Complete blood count medicine.disease 030104 developmental biology Endocrinology Case-Control Studies Pediatrics Perinatology and Child Health Gestation Female business Body mass index Biomarkers |
| Zdroj: | Journal of perinatal medicine. 44(3) |
| ISSN: | 1619-3997 |
| Popis: | The aim of this study was to evaluate the relationship between serum sirtuin-1 (SIRT1) level and neutrophil-lymphocyte ratio (NLR) with hyperemesis gravidarum (HG).Overall, 90 patients who presented with pregnancy between August 2013 and November 2014 were included in the study. The patients were divided into two groups: patients with HG (n=45) and patients without HG (control group [C]; n=45). The patients with comorbid conditions other than pregnancy (disease or medication) were excluded. In all patients, demographic data including age, body mass index (BMI), gestational week, and smoking status were recorded. Blood samples were drawn for complete blood count and measurements of blood lipid, liver enzymes, serum SIRT1, and insulin levels. NLR was calculated from CBC.No significant differences were detected in age, BMI, or GA between groups (P>0.05). Serum SIRT1 and NLR were found to be significantly higher in patients with HG compared with those in the control group (P=0.001 and 0.006, respectively).In HG, both SIRT1 level and NLR increased. In HG, this occurred as a response to metabolic alterations and potential inflammation. |
| Databáze: | OpenAIRE |
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