Repetitive Intrathecal VEGF165 Treatment Has Limited Therapeutic Effects after Spinal Cord Injury in the Rat
| Autor: | Sabien van Neerven, Jaap Patijn, Joachim Weis, Joerg Mey, Gary A. Brook, Charles Lambert, Ronald Deumens, Marco A. E. Marcus, Maarten van Kleef, Harry W.M. Steinbusch, Elbert A.J. Joosten |
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| Přispěvatelé: | Promovendi MHN, Anesthesiologie, Psychiatrie & Neuropsychologie, RS: MHeNs School for Mental Health and Neuroscience |
| Rok vydání: | 2010 |
| Předmět: |
Vascular Endothelial Growth Factor A
glia Angiogenesis neuroplasticity Motor Activity Neuroprotection Rats Sprague-Dawley chemistry.chemical_compound Glial Fibrillary Acidic Protein Animals Medicine Spinal cord injury Injections Spinal Spinal Cord Injuries Pain Measurement Analysis of Variance business.industry Therapeutic effect Recovery of Function Spinal cord medicine.disease Rats Vascular endothelial growth factor Lumbar Spinal Cord Treatment Outcome medicine.anatomical_structure Spinal Cord chemistry Hyperalgesia Anesthesia Neuropathic pain neuroprotection Female Neurology (clinical) central pain business |
| Zdroj: | Journal of Neurotrauma, 27(10), 1781-1791. Mary Ann Liebert Inc. |
| ISSN: | 1557-9042 0897-7151 |
| DOI: | 10.1089/neu.2010.1484 |
| Popis: | Neuropathic pain and motor deficits are detrimental consequences of injury to the spinal cord. In experimental settings, numerous neuroprotective agents are being explored for their therapeutic benefits. Vascular endothelial growth factor (VEGF) is an interesting candidate molecule in this respect since it is not only associated with angiogenesis, but also with neuroprotection and neurite growth. Other investigators have reported improved motor outcomes following intraparenchymal VEGF treatment. Here we demonstrate the therapeutic effects of daily intrathecal treatment of the contused thoracic rat spinal cord with the 165-isoform of VEGF during the first week after injury. We show that VEGF treatment resulted in a statistically significant attenuation of mechanical, but not thermal, hypersensitivity of the hindpaws, while motor deficits remained unaffected. Tissue sparing was also unchanged by VEGF treatment. Microglial responses at the lumbar spinal cord, which have been linked with spinal cord injury-induced hypersensitivity, were found to be unaffected by VEGF treatment. We conclude that repetitive intrathecal VEGF delivery has limited therapeutic effects on spinal cord injury outcome. |
| Databáze: | OpenAIRE |
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