Tumor host relations
| Autor: | H. M. Tillian, Wolfgang Schreibmayer, Erwin Schauenstein, R. J. Schaur, H. J. Semmelrock |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Cancer Research
medicine.medical_specialty Nitrogen balance Nitrogen Excretion Eating chemistry.chemical_compound Leucine Valine Internal medicine medicine Animals Amino Acids Isoleucine Sarcoma Yoshida chemistry.chemical_classification Creatinine Body Weight General Medicine Rats Amino acid Endocrinology Oncology chemistry Urea Ketoglutaric Acids Female |
| Zdroj: | Journal of Cancer Research and Clinical Oncology. 97:285-293 |
| ISSN: | 1432-1335 0171-5216 |
| Popis: | The continuous administration of physiological doses of the branched-chain amino acids leucine, isoleucine, and valine (Leu-Ile-Val) to Yoshida sarcoma-bearing rats caused a significant increase in the survival time by 32% and a significant reduction of tumor size after 3 weeks of growth by 33%. The shift of the nitrogen balance to negative values during the cachectic stage was delayed but not prevented. On the average, less nitrogen (-47 mg/day) were lost by Leu-Ile-Val treated rats compared with untreated tumor-bearing animals (-91 mg N/day). It appeared that Leu-Ile-Val increased the synthesis of carcass proteins, while it left the proteolysis rate unchanged, since the excretion of urea and creatinine was unaffected by these amino acids. The daily excretion of alpha-ketoglutarate, which is correlated with tumor size during the early stage of growth, was decreased during the first 2 weeks by Leu-Ile-Val, but remained for a longer period on a high level than in untreated tumor bearers. The results point to an improvement of the metabolic resistance against carcass protein depletion of the tumor-bearing host by the administration of branched-chain amino acids. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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