Tartrate-resistant acid phosphatase-positive cells in the synovial?cartilage junction and bone marrow during the progression of collagen-induced arthritis in adult rats

Autor: Ryota Teshima, Shinji Nishihara, Hiroyuki Mizumura, Yasuo Morio, Yuji Kishimoto
Rok vydání: 2004
Předmět:
Zdroj: Modern Rheumatology. 14
ISSN: 1439-7609
1439-7595
DOI: 10.1007/s10165-004-0278-5
Popis: We investigated the time-course changes in bone destruction in rats with collagen-induced arthritis (CIA). The synovial-cartilage junction (SCJ) and epiphyseal bone marrow of the femoral posteromedial condyle in CIA rats were evaluated histologically and immunohistologically at 2, 3, 4, 6, and 8 weeks after sensitization. Two weeks after sensitization, tartrate-resistant acid phosphatase (TRAP)-positive multinuclear cells formed resorption lacunae on the lateral side of the cortical bone under the SCJ. No resorption lacunae were observed in bone marrow. Three weeks after sensitization, resorption lacunae on the lateral side of the cortical bone expanded, but no bone marrow invasion by pannus was observed. In bone marrow, many TRAP-positive multinuclear cells appeared and formed resorption lacunae in subchondral bone. Four weeks after sensitization, cortical bone was destroyed, and pannus had invaded the bone marrow. After six weeks, trabecular bone and subchondral bone plate were extensively resorbed by TRAP-positive cells. Bone destruction in CIA began with the appearance of TRAP-positive cells on the lateral side of the cortical bone under the SCJ, followed by the TRAP-positive multinuclear cells in bone marrow, which were morphologically unconnected to the SCJ lesions. These histological findings suggested that bone destruction in the early stage of arthritis occurred in two anatomically different regions.
Databáze: OpenAIRE
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