Interleukin 6 and Interleukin 10 in Patients Before and After Lung Transplantation
| Autor: | Anna Łaszewska, Anita Stanjek-Cichoracka, Marian Zembala, Marek Ochman, Tomasz Stącel, Krzysztof Perć, Elżbieta Woźniak-Grygiel |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Gastroenterology Internal medicine medicine Lung transplantation Humans In patient Interleukin 6 Aged Transplantation COPD biology business.industry Interleukin-6 Middle Aged medicine.disease Interleukin-10 Interleukin 10 Cytokine Child Preschool biology.protein Population study Surgery Female business Body mass index Biomarkers Immunosuppressive Agents Lung Transplantation |
| Zdroj: | Transplantation proceedings. 52(7) |
| ISSN: | 1873-2623 |
| Popis: | The aim of the study was to investigate the serum concentration of cytokines (interleukin 6 [IL-6] and IL-10) in patients before and after lung transplantation (LTx). The studied groups consisted of 14 patients (9 men and 5 women aged 47.7 ± 11.4; body mass index [BMI] 21.9 ± 2.3) followed for up to 6 months after LTx and 29 patients (15 men and 14 women, age 49.2 ± 9.4; BMI 23.1 ± 3.7) who were considered for LTx. The study population consisted of patients with idiopathic lung disease (ILD; 8 vs 17) and patients with chronic obstructive pulmonary disease (COPD; 6 vs 12). Cytokine serum levels were assessed using commercially available enzyme-linked immunosorbent assay kits. Significantly lower levels of IL-10 were observed in the group of patients considered for LTx compared to those in recipients (1.8 ± 0.99 vs 5.1 ± 1.44; P = .000726). Significantly lower levels of IL-10 were observed in the group of patients with ILD considered for LTx compared to recipients (1.8 ± 0.95 vs 3.4 ± 1.16; P = .005984). There were no differences in levels of IL-10 in the group of patients with COPD. There were no differences in levels of IL-6 when the studied groups were compared. The present results introduce the cytokines IL-6 and IL-10 in patients before and after LTx. The procedure of LTx influenced increasing of plasma concentration of IL-10. Immunosuppressive drugs may affect IL-10 serum levels. Further studies are needed to evaluate whether analyzed cytokines could be used as biomarkers of clinical status in patients before and after LTx. |
| Databáze: | OpenAIRE |
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