Adiponectin is associated with cardio-metabolic traits in Mexican children
| Autor: | Roberto Karam-Araujo, Jesús Peralta-Romero, David Meyre, Jaime Gomez-Zamudio, Fernando Suarez, Miguel Cruz, Carolina Stryjecki, Ana I. Burguete-García, Akram Alyass, Juehua He, Hudson Reddon |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Blood Glucose Male medicine.medical_specialty Adolescent lcsh:Medicine Blood Pressure Overweight Polymorphism Single Nucleotide Article Body Mass Index 03 medical and health sciences 0302 clinical medicine Waist–hip ratio Insulin resistance Metabolic Diseases Internal medicine medicine Humans Insulin Obesity lcsh:Science Child Mexico Triglycerides Dyslipidemias Multidisciplinary Adiponectin business.industry lcsh:R Cholesterol LDL medicine.disease 030104 developmental biology Endocrinology Glucose Child Preschool Homeostatic model assessment lcsh:Q Female medicine.symptom Insulin Resistance Receptors Adiponectin business Body mass index 030217 neurology & neurosurgery Dyslipidemia |
| Zdroj: | Scientific Reports BASE-Bielefeld Academic Search Engine Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019) |
| ISSN: | 2045-2322 |
| Popis: | The adipocyte-derived adiponectin hormone bridges obesity and its cardio-metabolic complications. Genetic variants at the ADIPOQ locus, in ADIPOR1, and ADIPOR2 have been associated with adiponectin concentrations and cardio-metabolic complications in diverse ethnicities. However, no studies have examined these associations in Mexican children. We recruited 1 457 Mexican children from Mexico City. Six genetic variants in or near ADIPOQ (rs182052, rs2241766, rs266729, rs822393), ADIPOR1 (rs10920533), and ADIPOR2 (rs11061971) were genotyped. Associations between serum adiponectin, genetic variants, and cardio-metabolic traits were assessed using linear and logistic regressions adjusted for age, sex, and recruitment center. Serum adiponectin concentration was negatively associated with body mass index, waist to hip ratio, low-density lipoprotein cholesterol, total cholesterol, triglycerides, fasting glucose, fasting insulin, homeostatic model assessment of insulin resistance, dyslipidemia and overweight/obesity status (7.76 × 10−40 ≤ p ≤ 3.00 × 10−3). No significant associations between genetic variants in ADIPOQ, ADIPOR1, and ADIPOR2 and serum adiponectin concentration were identified (all p ≥ 0.30). No significant associations between the six genetic variants and cardio-metabolic traits were observed after Bonferroni correction (all p −4). Our study suggests strong associations between circulating adiponectin concentration and cardio-metabolic traits in Mexican children. |
| Databáze: | OpenAIRE |
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