HLA-G Expression in the Skin of Patients with Systemic Sclerosis
| Autor: | João Francisco Marques-Neto, Eliane Maria Ingrid Amstalden, Eduardo Antônio Donadi, A.C. Biral, Isabela Jubé Wastowski, Janaina Cristiana de Oliveira Crispim, Philippe Moreau, Gustavo Martelli Palomino, Edgardo D. Carosella, Percival D. Sampaio-Barros, Diane M. Rassi |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Systemic disease Pathology Immunology medicine.disease_cause Scleroderma Autoimmunity Rheumatology HLA Antigens Internal medicine Immunopathology Skin Ulcer medicine Humans Immunology and Allergy Telangiectasis skin and connective tissue diseases Skin HLA-G Antigens Autoimmune disease Scleroderma Systemic integumentary system business.industry Histocompatibility Antigens Class I Middle Aged Prognosis medicine.disease Immunohistochemistry Connective tissue disease Survival Rate Female business Biomarkers Brazil |
| Zdroj: | The Journal of Rheumatology. 36:1230-1234 |
| ISSN: | 1499-2752 0315-162X |
| Popis: | Objective.To determine HLA-G expression in skin biopsies from patients with systemic sclerosis (SSc), and its association with epidemiological, clinical, and laboratory variables and survival.Methods.Paraffin-embedded skin biopsies obtained from 21 SSc patients (14 limited SSc, 7 diffuse SSc) and from 28 healthy controls were studied. HLA-G expression was evaluated by immunohistochemistry.Results.HLA-G molecules were detected in 57% of skin biopsies from patients with SSc (9 from limited SSc, 3 from diffuse SSc), whereas no control sample expressed HLA-G (p = 0.000004). In patients, HLA-G molecules were consistently observed within epidermal and some dermal cells. HLA-G expression was associated with a lower frequency of vascular cutaneous ulcers (p = 0.0004), telangiectasias (p = 0.008), and inflammatory polyarthralgia (p = 0.02). After a 15-year followup, SSc patients who exhibited HLA-G survived longer than patients who did not.Conclusion.HLA-G is expressed in skin biopsies from patients with SSc, and this is associated with a better disease prognosis. This suggests a modulatory role of HLA-G in SSc, as observed in other skin disorders. |
| Databáze: | OpenAIRE |
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