Postprandial Lipid Concentrations and Daytime Biological Variation of Lipids in a Healthy Chinese Population
| Autor: | Qian Cai, Dagan Yang, Yunxian Zhou, Xinglun Qi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male China Apolipoprotein B Clinical Biochemistry Postprandial lipids 030204 cardiovascular system & hematology Triglyceride 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Animal science Asian People Biological variation Medicine Humans Triglycerides Chinese population Clinical Chemistry biology Apolipoprotein A-I business.industry Biochemistry (medical) Cholesterol HDL General Medicine Venous blood Fasting Cholesterol LDL Postprandial Period Lipids Healthy Volunteers 030104 developmental biology Postprandial Cholesterol chemistry biology.protein Non-fasting Apolipoprotein A1 lipids (amino acids peptides and proteins) Original Article Female Analysis of variance business |
| Zdroj: | Annals of Laboratory Medicine |
| ISSN: | 2234-3814 2234-3806 |
| Popis: | Background Several latest guidelines and consensus statements from Europe and the United States specify that there is no need for fasting prior to routine lipid tests. However, the latest Chinese guidelines still recommend fasting tests owing to a lack of local evidence. This study aimed to investigate postprandial lipid concentrations and daytime biological variation of lipids in a healthy Chinese population. Methods Venous blood samples were collected from 41 ostensibly healthy Chinese volunteers at five time points during the day (06:30, 09:00, 12:00, 15:00, and 18:30). The same batch of reagents was used to determine lipid concentrations. A nested ANOVA was performed to calculate within-subject biological variation (CV(I)) and between-subject biological variation (CV(G)). Results Postprandial concentrations of triglyceride were higher than fasting concentrations, with the maximum change occurring at 12:00 (0.5 hours after lunch, 0.21±0.65 mmol/L difference). The daytime biological variation of triglycerides was relatively high (CV(I)=25%, CV(G)=35.9%). The postprandial concentrations of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apolipoprotein A1, and apolipoprotein B were mostly lower than the fasting concentrations, and their daytime biological variations were relatively low (CV(I)=2.4-4.4%, CV(G)=11.8-18.7%). Conclusions As most daytime lipid concentrations changed only slightly, non-fasting samples could be used for routine lipid tests. However, in cases of abnormal postprandial triglyceride concentrations, dietary factors and fasting time should be considered when interpreting the results. |
| Databáze: | OpenAIRE |
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