The Prevalence and Incidence of Latent Tuberculosis Infection and Its Associated Factors among Village Doctors in China
| Autor: | Carol Y. Rao, Fei Gao, Lixia Wang, Fei Zhao, Guangxue He, Kai Lu, Guoxin Han, Shufang Guo, Haiying Fan, Jing An, Yongchao Xiong, Yu-Dan Song, John D. Klena, Fengming Duan, Liping Ren, Chunru Wu, Yu Wang, Daiqin Yan, Yueyun Hou, Jun Yang, Yuan Li, Yali Wang, Haiyan Gao, Hui Guo, Xiaoyan Duan, Meng-Jie Geng, Jianbo Li, Yanlin Zhao, Dongmei Hu, Shiming Cheng, Fangfang Gao, Guoming He |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male China Pediatrics medicine.medical_specialty Longitudinal study Tuberculosis Science Tuberculin Young Adult Latent Tuberculosis Risk Factors Epidemiology Odds Ratio Prevalence medicine Humans Infection control Longitudinal Studies Community Health Workers Multidisciplinary Latent tuberculosis Tuberculin Test business.industry Incidence Incidence (epidemiology) Odds ratio Middle Aged bacterial infections and mycoses medicine.disease 3. Good health Medicine Female business Interferon-gamma Release Tests Research Article Demography |
| Zdroj: | PLoS ONE PLoS ONE, Vol 10, Iss 5, p e0124097 (2015) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0124097 |
| Popis: | BackgroundChina is a high tuberculosis (TB) burden country. More than half of acute TB cases first seek medical care in village doctors' clinics or community health centers. Despite being responsible for patient referral and management, village doctors are not systematically evaluated for TB infection or disease. We assessed prevalence and incidence of latent TB infection (LTBI) among village doctors in China.Methods and findingsA longitudinal study was conducted in Inner Mongolia Autonomous Region. We administered a questionnaire on demographics and risk factors for TB exposure and disease; Tuberculin skin testing (TST) and QuantiFERON-TB Gold in-tube assay (QFT-GIT) was conducted at baseline and repeated 12 months later. We used a logistic regression model to calculate adjusted odds ratios (ORs) for risk factors for TST and QFT-GIT prevalence and incidence. At the time of follow up, 19.5% of the 880 participating village doctors had a positive TST and 46.0% had a positive QFT-GIT result. Factors associated with TST prevalence included having a BCG scar (OR = 1.45, 95%CI 1.03-2.04) and smoking (OR = 1.69, 95%CI 1.17-2.44). Risk factors associated with QFT-GIT prevalence included being male (OR = 2.17, 95%CI 1.63-2.89), below college education (OR=1.42, 95%CI 1.01-1.97), and working for ≥25 years as a village doctor (OR = 1.64, 95%CI 1.12-2.39). The annual incidence of LTBI was 11.4% by TST and 19.1% by QFT-GIT. QFT-GIT conversion was associated with spending 15 minutes or more per patient on average (OR = 2.62, 95%CI 1.39-4.97) and having BCG scar (OR = 0.53, 95%CI 0.28-1.00).ConclusionsPrevalence and incidence of LTBI among Chinese village doctors is high. TB infection control measures should be strengthened among village doctors and at village healthcare settings. |
| Databáze: | OpenAIRE |
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