Transient fall in serum salicylate levels following intraarticular injection of steroid in patients with rheumatoid arthritis
| Autor: | Abraham Shore, Philip A. Baer, Robert L. Ikeman |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Male medicine.medical_specialty Hospitalized patients medicine.medical_treatment Immunology Methylprednisolone Injections Intra-Articular Steroid Arthritis Rheumatoid Rheumatology medicine Humans Immunology and Allergy Drug Interactions Pharmacology (medical) In patient Child Patient compliance Lead (electronics) Aged business.industry Middle Aged medicine.disease Salicylates Surgery Anesthesia Rheumatoid arthritis Toxicity Female Salicylic Acid business |
| Zdroj: | Arthritis & Rheumatism. 30:345-347 |
| ISSN: | 1529-0131 0004-3591 |
| DOI: | 10.1002/art.1780300315 |
| Popis: | Our study of 13 hospitalized patients with rheumatoid arthritis examined the effect of intraarticular injection of steroid on serum salicylate levels. A mean decrease in serum salicylate levels of 42 +/- 14.5% was observed in 12 patients within 12-36 hours post-injection (P less than 0.005). This interaction, though transient, may be very significant clinically. It may lead to erroneous conclusions concerning patient compliance, unwarranted increases in salicylate dosage and resultant toxicity, and delay of appropriate therapeutic maneuvers. |
| Databáze: | OpenAIRE |
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