Stem cells and enhanced healing of chronic tympanic membrane perforation
| Autor: | Joris J.J. Dirckx, Magnus Von Unge, Petri Olivius, Malou Hultcrantz, Anisur Rahman |
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| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Tympanic Membrane Treatment outcome Healing time Rats Sprague-Dawley Microscopy Electron Transmission Myringoplasty medicine Animals Tympanic Membrane Perforation Wound Healing business.industry Mesenchymal stem cell Tympan Follow up studies General Medicine Rats Surgery Disease Models Animal Interferometry Sound Treatment Outcome Otorhinolaryngology Chronic Disease Stem cell business Follow-Up Studies Stem Cell Transplantation Moire interferometry Biomedical engineering |
| Zdroj: | Acta oto-laryngologica |
| ISSN: | 1651-2251 0001-6489 |
| Popis: | Conclusions. Important information about the basic reparative process of tympanic membrane (TM) healing is shown, which can be incorporated for further clinical understanding. This provides a basis for the exploration of stem cell treatment for TM perforations and holds promise for future improvements. Objectives. This study aimed to analyse the healing of TM perforation by using stem cells and the stiffness of the membrane was tested in an acute and long-term study. Materials and methods. Sprague-Dawley rats were used in a model of TM perforation. The perforation was performed with a laser system. Stem cells were applied and the healing time and morphological analysis were performed with light and transmission electron microscope. Stiffness was examined by moire interferometry. Results. The stiffness of the perforated and healed TM was restored after just 2 weeks. In the chronic perforation model, mesenchymal stem cells enhanced the healing. |
| Databáze: | OpenAIRE |
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