Unilateral retinoblastoma; natural history and an age-based protocol in 248 patients
Autor: | Abdallah E Shelil, M Saad Zaghloul, Radwa Nour, Hossam El Zomor, Adel Aleieldin, Anas M. Saad, Ahmad S. Alfaar, Hala Taha |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
medicine.medical_specialty
medicine.medical_treatment Retinal Neoplasms Enucleation Clinical state Disease Article Eye Enucleation 03 medical and health sciences 0302 clinical medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Child Retrospective Studies Chemotherapy Retinoblastoma business.industry Infant Retrospective cohort study Paediatrics medicine.disease Retinal diseases Neoadjuvant Therapy Surgery Natural history Ophthalmology 030220 oncology & carcinogenesis 030221 ophthalmology & optometry business Unilateral Retinoblastoma |
Zdroj: | Eye |
ISSN: | 1476-5454 0950-222X |
Popis: | Objectives We aimed to study the clinical state and prognosis of patients with unilateral retinoblastoma who were being treated at a paediatric comprehensive cancer centre in a limited-resource country, to assess the different phases of treatment and the success of different, more complex real-life models. Subjects In this retrospective study, we created a snapshot of our retinoblastoma database for the period between 2007 and 2015. Patients whose data were included in the study were followed up until 2016. Out of a total of 744 screened patients, we included data of 248 patients who had been diagnosed with unilateral retinoblastoma. Results As classified as per the International Retinoblastoma Classification, 1 patient presented with group A, 21 with group B, 39 with group C, 104 with group D and 83 with group E retinoblastoma. Chemotherapy was the initial line of treatment in 115 patients and enucleation in 133 others. Later, 141 patients (56.9%) required further management. Patients had a mean ocular survival time of 20.8 months. Nine patients developed extraocular disease at a later stage of management: five after upfront enucleation and four after neoadjuvant chemotherapy. Mean overall survival time stood at 90.2 months. Four and three deaths were recorded in groups D and E, respectively. A single patient died in the initial chemotherapy arm, while six passed away in the initial enucleation arm. Conclusion Our study highlights the importance of initial chemotherapy and close follow-up after enucleation of classes D and E affected eyes even in absence of germline mutations. |
Databáze: | OpenAIRE |
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