Structure of a novel Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase inhibitor KS-619-1

Autor:	T, Yasuzawa, M, Yoshida, K, Shirahata, H, Sano
Rok vydání:	1987
Předmět:	Pharmacology Magnetic Resonance Spectroscopy Phosphodiesterase Inhibitors Spectrum Analysis Drug Discovery Mass Spectrometry Streptomyces
Zdroj:	The Journal of Antibiotics. 40:1111-1114
ISSN:	1881-1469 0021-8820
DOI:	10.7164/antibiotics.40.1111
Popis:	The structure of KS-619-1, a potent inhibitor of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase, was determined to be 8,13-dioxo-3-(2-oxopropyl)-5,6,8,13-tetrahydro-1,7,9,11- tetrahydroxybenz[a]naphtacene-2-carboxylic acid by spectral studies of KS-619-1 and its methyl derivative.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a822508b50f3f5c9a91bf1a0d4e31ff1 https://doi.org/10.7164/antibiotics.40.1111 Zobrazit plný text záznamu